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Diss Factsheets
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EC number: 807-715-4 | CAS number: 1354569-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The test substance was not readily degradable in a screening non-GLP test with OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). In addition, the test substance was not inhibitory at 2.3 mg/L nominal concentration to microorganisms. The result is considered as valid with restrictions (Klimisch 2), and selected as the key study.
It needs to be noted that the 2.3 mg/L nominal concentration highly exceeds the determined water solubility of the test substance.
The form of the test material in the solution may have varied (dissolved, suspended, emulsified). However, in principle the OECD 301D method is suitable for poorly water soluble, volatile and adsorptive substances.
There is also weight of evidence of rapid degradation.The test substance was estimated to be readily biodegradable by BIOWIN 4.10 QSAR modelling. The result of the QSAR modelling is considered as valid, and is rated as reliable with restrictions (Klimisch 2) and used as weight of evidence for classification and labelling and PBT assessment.
The STPWIN fugacity-based QSAR Level III model estimated the test substance to biodegrade 78.15 % in a conventional wastewater treatment plant that uses activated sludge secondary treatment. The estimate for total removal % was 99.99 % (recommended maximum 95 %). The modelling result can be considered as reliable with restrictions (Klimisch 2), as the model may overpredict biodegradability of structurally analogous compounds when using the BIOWIN output and EPA Draft Method option.
In conclusion, bis(2 -ethylhexyl)citraconate is assessed as not readily biodegradable for classification and labelling based on a screening non-GLP OECD 301 D Test. In addition, the substance was observed not to inhibit growth of micro-organisms at 2.3 mg/L nominal concentration. The available QSAR models however provide some weight of evidence of ultimate biodegradability, for which no valid experimental test result is available. The BIOWIN model is however assessed to overpredict biodegradability of structurally analogous compounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.