Registration Dossier
Registration Dossier
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EC number: 200-625-0 | CAS number: 66-27-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- determination of eye irritation for CAS no: 124-63-0
- Author:
- HSDB
- Year:
- 2 018
- Bibliographic source:
- U.S. National Library of Medicine National Institutes of Health, Health & Human Services; 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An eye irritation study was conducted on rabbits for chemical Methanesulphonyl chloride (CAS no: 124-63-0) to assess its ocular irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- Methanesulphonyl chloride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Mesyl chloride (MSC)
- Molecular formula: CH3ClO2S
- Molecular weight: 110.1324 g/mol
- Substance type: Organic
- Physical state: liquid
- InChI: 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
- Smiles: COS(=O)(=O)C
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Single application
- Duration of treatment / exposure:
- 20 to 30 sec after instillation
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Instillation of test chemical reduced the response, but corneal opacity and congestion of the iris with no pupillary light reaction were still noted.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The chemical Methanesulphonyl chloride (CAS no: 124-63-0) was considered as severely irritating to the eyes of rabbits.
- Executive summary:
An irritation study was conducted on rabbits for chemical Methanesulphonyl chloride (CAS no: 124-63-0) to assess its ocular irritation potential.
The rabbits were treated with single application of Methanesulphonyl chloride which caused irrigation of the eye 20 to 30 sec after instillation reduced the response, but corneal opacity and congestion of the iris with no pupillary light reaction were still noted.
Hence the chemical Methanesulphonyl chloride (CAS no: 124-63-0)was considered as severely irritating to the eyesof rabbits.
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