Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-288-2 | CAS number: 1119-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Two guideline in vivo skin irritation studies (OECD404) have been performed with technical grade and purified decan-1,2-diol respectively and very similar results were observed in the two studies in New Zealand White rabbits which resulted in a non-classification for skin irritation under CLP Regulation (EC) No. 1272/2008.
A regulatory in vivo eye irritation study in a rabbit also indicated irreversible damage and a Category 1 classification which was supported by positive results in a non-Regulatory HET-CAM test.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Performed in accordance with published test guidelines (OECD404 and EU B.4) and in accordance with GLP.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd, Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12 to 16 weeks old
- Weight at study initiation: 2.0- 3.5 kg
- Housing: The animals were individually housed in suspended metal cages
- Diet (e.g. ad libitum): Free access to food (STANRAB SQC Rabbit Diet, Special Diets Services Ltd, Witham, Essex, UK)
- Water (e.g. ad libitum): Free access to mains drinking water a
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23°C
- Humidity (%): 30 to 70%
- Air changes (per hr): at least 15 per hour
- Photoperiod (hrs dark / hrs light): Twelve hours continuous light (06:00 to 18:00) and twelve hours darkness. - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g
- Concentration (if solution): in 0.5mL of water (i.e. 1g/mL)
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5mL
- Concentration (if solution): 1g/mL - Duration of treatment / exposure:
- Four hours after application the corset and patches were removed from each animal and any residual test material removed by gentle swabbing with cotton wool soaked in distilled water.
- Observation period:
- Approximately one hour following the removal of the patches, and 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal flank area
- Type of wrap if used: elasticated corset
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: 4
SCORING SYSTEM: The test material was classified according to Draize (1959) Dermal Toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Association of Food and Drug Officials of the United States, Austin, Texas, p. 47.
The test sites were scored according to the following scale:
ERYTHEMA AND ESCHAR FORMATION
- No erythema (0)
- Very slight eryhthema (barely perceptible) (1)
- Well defined eryhtema (2)
- Moderate to severe erythema (3)
- Severe eryhthema (beet redness) to slight eschar formation (injuries in depth) (4)
OEDEMA FORMATION
- No oedema (0)
-Very slight oedema (1)
- Slight oedema (edges of area well-defined by definite raising) (2)
- Moderate oedema (raised approximately 1 millimetre) (3)
- Severe oedema (raised maore than 1 millimetre and extending beyond the area of exposure (4) - Irritation parameter:
- primary dermal irritation index (PDII)
- Remarks:
- Total score 19 giving average over 6 readings of 3.2
- Basis:
- mean
- Time point:
- other: average of all scores after 24 and 72hours
- Score:
- ca. 3.2
- Reversibility:
- fully reversible
- Remarks:
- 14 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- values for rabbit 127 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14
- Remarks on result:
- other: values at the 3 time points were 2, 1, and 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- values for rabbit no 122 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: values at each of the 3 time points were 2, 2, and 2
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- values for rabbit no 125 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 1.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14days
- Remarks on result:
- other: values at the2 time points were 2, 1, and 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- values for rabbit no127 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 1.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7days
- Remarks on result:
- other: values at the 3 time points were 2, 1, and 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- value for rabbit no 122 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: values at the three time points were 2,2 and 2
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- value for rabbit no 125 male
- Time point:
- other: mean of values at 24, 48 and 72 hours
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: values at three time points were 1, 1, and 1
- Irritant / corrosive response data:
- Well-defined erythema was noted at all treated skin sites one hour after patch removal and at the 24-hour observation. Well-defined erythema persisted at one treated skin site with very slight erythema at two treated skin sites at the 48 and 72-hour observations.
Slight oedema was noted at all treated skin sites one hour after patch removal with very slight to slight oedema at the 24, 48 and 72-hour observations.
Loss of skin elasticity was noted at one treated skin site at the 48 and 72-hour observations. Crust formation was noted at one treated skin site with slight desquamation at two treated skin sites at the 7-day observation.
Treated skin sites appeared normal at the 14-day observation. - Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Draize PDII classification
- Conclusions:
- While some degree of irritation was observed, particularly in one animal, the degree of erythema an oedema was not of sufficient magnitude (mean values of <2) to warrant classification as a Skin Irritant Category 2 under CLP Regulation (EC) No. 1272/2008.
The relevant criteria which were NOT MET were
Mean value of ≥ 2,3 - ≤ 4,0 for erythema/eschar or for oedema in at least 2 of 3 tested animals from gradings at 24, 48 and 72 hours after patch removal or, if reactions are delayed, from grades on 3 consecutive days after the onset of skin reactions; or
(2) Inflammation that persists to the end of the observation period normally 14 days in at least 2 animals, particularly taking into account alopecia (limited area), hyperkeratosis, hyperplasia, and scaling; or
(3) In some cases where there is pronounced variability of response among animals, with very definite positive effects related to chemical exposure in a single animal
- Executive summary:
The study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method was designed to meet the requirements of the following: a) OECD Guidelines for the Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion- (adopted 17 July 1992) b) Commission Directive 92/69/EEC Method B4 Acute Toxicity (Skin Irritation). No corrosive effects were noted. However, a single 4-hour, semi-occlusive application of the test material to the intact skin of three rabbits produced well-defined erythema and slight oedema. Loss of skin elasticity, crust formation and slight desquamation were also noted.
Treated skin sites appeared normal at the 14-day observation.
Based on these data a primary irritation index of 3.2 was calculated and this classifies the test substance as a moderate irritant to rabbit skin according to the Draize classification scheme. However, in the three animals tested, the test material did not demonstrate a sufficient degree of erythema or oedema to warrant classification as a Category 2 Skin Irritant (i.e. mean values were all <2), and so is considered to be non-irritating under CLP Regulation (EC) No. 1272/2008 (Version 4.1, 2015).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A guideline study conducted in accordance with OECD test guideline 405 and to GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:David Percival Ltd, Moston, Sandbach, Cheshire, UK.
- Age at study initiation: Twelve to sixteen weeks old.
- Weight at study initiation: Weight range of 2.0 to 3.5 kg.
- Housing: The animal was housed in a suspended metal cage
- Environmental enrichment: wooden chew blocks and cardboard fun tunnels
- Diet (e.g. ad libitum): Free access to food
- Water (e.g. ad libitum): Free access to mains drinking water
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23°C
- Humidity (%): 30 to 70%
- Air changes (per hr): The rate of air exchange was at least fifteen changes per hour.
- Photoperiod (hrs dark / hrs light): Lighting was controlled by a time switch to give twelve hours continuous light (06:00 to 18:00) and twelve hours darkness - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1mL - approximately 74mg - Duration of treatment / exposure:
- 21 days
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- One
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not done
SCORING SYSTEM: According to Draize Scale for Scoring Ocular Irritation at 1 hour, 24, 48 and 72 hours with additional observations at 27 and 21 days
TOOL USED TO ASSESS SCORE: Standard ophthalmoscope - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: Mean of scores at 24, 48 and 72 hours
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 21
- Remarks on result:
- other: individual scores at the three time points were 1, 1, and 1 - vacularisation of cornea still evident after 21 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: Mean of scores at 24, 48 and 72 hours
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 14
- Remarks on result:
- other: scores at the three time points were 1, 1 and 1
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: Mean of scores at 24, 48 and 72 hours
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14
- Remarks on result:
- other: scores at the three time points were 2, 2 and 2
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: Mean of scores at 24, 48 and 72 hours
- Score:
- ca. 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14
- Remarks on result:
- other: scores at the three time points were 2, 1 and 1
- Irritant / corrosive response data:
- Scattered or diffuse corneal opacity was noted in the treated eye one hour after treatment and at subsequent 24, 48, 72-hour, 7, 14 and 21-day observations. Vascularisation of the cornea with a generalised in growth of vessels for approximately 2 to 3 mm was noted in the treated eye at the 7, 14 and 21-day observations.
Iridial inflammation was noted in the treated eye one hour after treatment and at the 24, 48, 72-hour and 7-day observations.
Moderate conjunctival irritation was noted in the treated eye one hour alter treatment and at the 24, 48, 72-hour and 7-day observations.
The corneal vascularisation noted in the treated eye was considered to be irreversible. - Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU CLP
- Conclusions:
- The test material produced irreversible ocular damage and was considered to be a Category 1 eye irritant (irreversible effects on the eye) and requires the Hazard Statement H318 "Causes serious eye damage"
- Executive summary:
The study was performed to assess the irritancy potential of the test material to the eye of the New Zealand White rabbit. The method was designed to meet the requirements of the following: a) OECD Guidelines for the Testing of Chemicals No. 405 "Acute Eye Irritation/Corrosion" (adopted 24 February 1987) and b) Commission Directive 92/69/EEC Method B5 Acute Toxicity (Eye Irritation).
A single application of the test material to the non-irrigated eye of one rabbit produced irreversible effects. Reactions included scattered or diffuse corneal opacity, iridial inflammation, moderate conjunctival irritation and vascularisation of the cornea with a generalised ingrowth of vessels for approximately 2 to 3 mm.
The test material produced irreversible ocular damage and was considered to be a Category 1 eye irritant (irreversible effects on the eye) and requires the Hazard Statement H318 "Causes serious eye damage".
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In both regulatory in vivo skin irritation studies, a single 4-hour, semi-occluded application of the test material to the intact skin of three rabbits produced well-defined erythema and slight oedema. With the technical material effects were fully reversible in 14 days in 2 animals, but in the 3rd animal a light brown discolouration of the epidermis, loss of skin elasticity and flexibility, crust formation, reduced regrowth of fur, and a hardened light brown coloured scab was observed which prevented evaluation of erythema and oedema. These effects, together with a glossy skin were not fully reversible in 14 days for this animal. With the purified material there was a loss of skin elasticity, crust formation and slight desquamation, but treated skin sites in all three animals appeared normal at the 14-day observation time point.
Based on these data a primary irritation index of 3.2 was calculated and this classifies the test substance as a moderate irritant to rabbit skin according to the Draize classification scheme. However, in the three animals tested, the test material did not demonstrate a sufficient degree of erythema or oedema to warrant classification as a Category 2 Skin Irritant (i.e. mean values were all <2), and so is considered to be non-irritating under CLP Regulation (EC) No. 1272/2008.
A single application of the test material to the non-irrigated eye of one rabbit produced irreversible effects. Reactions included scattered or diffuse corneal opacity, iridial inflammation, moderate conjunctival irritation and vascularisation of the cornea with a generalised ingrowth of vessels for approximately 2 to 3 mm which was not reversible after 21 days observation.
The test material produced irreversible ocular damage and was considered to be a Category 1 eye irritant (irreversible effects on the eye) and requires the Hazard Statement H318 "Causes serious eye damage".
Justification for selection of skin irritation / corrosion endpoint:
Guideline study conducted according to OECD404 and EU B.4 and to GLP. The study is the most recent of two similar studies in which a purified test material was used in the selected key study in comparison with technical material used in the supporting study.
Justification for selection of eye irritation endpoint:
A guideline study conducted in accordance with OECD test guideline 405 and to GLP.
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: corrosive
Justification for classification or non-classification
Decan-1,2-diol was not classifiable as a skin irritant under CLP Regulation (EC) No. 1272/2008 since, for the three animals tested in each of the two studies the mean values for erythema/eschar or oedema were all <2.
However, decan-1,2-diol did produce irreversible ocular damage and was considered to be a Category 1 eye irritant (irreversible effects on the eye) and requires the Hazard Statement H318 "Causes serious eye damage".
Not classifiable as a Skin Irritant
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)