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EC number: 408-200-3 | CAS number: 63187-91-7 FRESCOLAT MGA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 24 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 240 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 2.4 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 11.4 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.16 mg/kg sediment dw
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.016 mg/kg sediment dw
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.018 mg/kg soil dw
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 6.67 mg/kg food
- Assessment factor:
- 300
Additional information
Details on the calculation of the PNECs for sediment and soil:
PNEC sediment - fresh water:
PNEC sediment = (Ksusp-water/RHOsediment)*PNECwater*1000
with:
* Ksusp-water = 1.655 (calculated in EUSES on basis of log Koc of 1.48)
* RHOsusp = 1150 kg/m3 (bulk density of suspended matter)
* PNECwater = 0.024 mg/L
PNEC sediment - marine water:
PNEC sed = (Ksusp-water/RHOsediment)*PNECsaltwater*1000
with:
* Ksusp-water = 1.655 (calculated in EUSES on basis of log Koc of 1.48)
* RHOsusp = 1150 kg/m3 (bulk density of suspended matter)
* PNECmarine water = 0.0024 mg/L
PNEC soil:
PNEC soil = (Ksoil-water/RHOsoil)*PNECwater*1000
with:
* Ksoil-water = 1.1 (calculated in EUSES based on log Koc of 1.48)
* RHOsoil = 1700 kg/m3 (bulk density of wet soil)
* PNECwater = 0.024 mg/L
PNEC oral:
PNEC oral = NOEC / AF
and
NOEC = NOAEL * CONV
with:
* NOAEL = 200 mg/kg bw*d (based on no mortality observed in 28d repeated dose study)
* CONV = 10 for rats <= 6 weeks
* AF = 300
Conclusion on classification
The following aquatic toxicity data are available for 3 trophic levels (fish, daphnia, algae):
* fish: 96h LC50: 24 mg/L
* daphnia: 48h EC50: 62 mg/L
* algae: 72h ErC50: 80 mg/L (acute)
* algae: 72h ErC10: 31.4 mg/L (chronic)
The following environmental fate data are available:
* Log Kow = 3.04
* Not rapidly biodegradable
CLP classification
Acute aquatic hazard
The lowest acute aquatic toxicity value is > 1 mg/L (lowest value is 24 mg/L for fish). Substance is not to be classified for acute aquatic toxicity and consequently, determination of an M-factor is not applicable.
Chronic aquatic hazard:
There is only adequate chronic toxicity information available on algae. Consequently, the classification is to be determined via two different approaches. The first one being based on the available chronic information in combination with the degradation potential of the substance (Table 4.1.0(b)(i)) and the second one based on acute aquatic toxicity information in combination with the degradation and bioaccumulation potential (Table 4.1.0(b)(iii)).
· Based on the available chronic information (Table 4.1.0(b)(i)): The lowest EC10 value is > 1 mg/L, hence no classification is warranted based on this approach.
· Based on the surrogate acute classification scheme (Table 4.1.0(b)(iii)): The lowest acute toxicity value is between 10 a and 100 mg/L (fish) and the substance is not rapidly biodegradable. Consequently, Category Chronic 3 (H412) is applicable.
· Based on the available information, no M-factor is required.
Conclusion: Based on the most stringent classification, the substance is to be classified as Category Chronic 3 (H412).
DSD classification
According to the criteria described in section 5.2.1.2 of Annex VI to Directive 67/548/EEC (Dangerous Substances Directive), a substance shall be classified as R52/53 in case the LC50 values determined in acute toxicity tests are in the range of 10-100 mg/L, and the substance is not readily biodegradable. As a consequence, classification with R52/53 under DSD is required in the current case.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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