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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: no effects observed at 2000 mg/kg bw, the highest dose tested (equivalent to OECD 401, GLP).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
2 000 mg/kg bw

Additional information

[2-(perfluorohexyl)ethyl]trimethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP (BSL Bioservice, 2015a). The undiluted test substance was administered by gavage to two groups, each of 3 female rats. The rats were dosed at 2000 mg/kg bw. There were no deaths and no signs of systemic reaction to treatment during the fourteen day observation period. All animals achieved satisfactory bodyweight gains throughout the study. The LD₅₀ was determined to be >2000 mg/kg bw.

Justification for classification or non-classification

Based on the available acute oral data, [2-(perfluorohexyl)ethyl]trimethoxysilane does not require classification for acute toxicity according to Regulation (EC) No 1272/2008.