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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Article published in established peer-reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
A Toxicological Investigation of Some Acute, Short-Term, and Chronic Effects of Administering Di-2-Ethylhexyl Phthalate (DEHP) and Other Phthalate Esters
Author:
Lawrence, W.H., Malik, M., Turner, J.E., Singh, A.R., and Autian, J.
Year:
1975
Bibliographic source:
Journal of Environmental Research, 9, 1-11.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
di-isobutyl phthalate
IUPAC Name:
di-isobutyl phthalate

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Details on exposure:
Observation period : 7 days post-doe (end-point - mortality)
Doses:
Not specified
No. of animals per sex per dose:
Groups of 10 males
Statistics:
The LD50 95% confidence interval and slope were calculated from the 7-day mortality data by Cornfield and Mantels' (1950) modification of Karber's method.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3.99 other: g/kg bw
Based on:
not specified
95% CL:
>= 3.91 - <= 4.08
Remarks on result:
other: IP LD50 also reported as 3.84 mL/kg bw

Any other information on results incl. tables

Results: IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg

Applicant's summary and conclusion

Conclusions:
Results:
IP LD50 3.99 g/kg (95% confidence interval 3.91 – 4.08); IP LD50 3.84 mL/kg