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EC number: 700-220-3 | CAS number: 99636-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Dermal irritation was evaluated in a acute dermal study (24 hours treatment, occlusive coverage of test sites)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Dermal irritation was evaluated in an acute dermal toxicity study performed according to EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Remarks:
- United States Environmental Protection Agency TSCA: Good Laboratory Practice Standards, 40 CFR 792
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): s-MOIPA
- Physical state: clear, light-yellow liquid
- Purity test date: 94.1 - 95.3%
- Lot/batch No.: 7/11/97
- Storage condition of test material: the test material was stored at room temperature.
Test animals
- Species:
- rabbit
- Strain:
- other: Hra:(NZW)SPF
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): the amount of test material applied to the test site in a thin and uniform layer was approximately 0.006 g/cm2 (500 mg/kg dose level) to 0.04 g/cm2 (3000 mg/kg dose level). - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 5 males and 5 females (except the 3000 mg/kg dose group, where the treatment was interrupted for humane reasons, after 3 males were treated)
- Details on study design:
- TEST SITE
- Area of exposure: 180 cm2
- % coverage: occlusive
- Type of wrap if used: the area of application was covered with a zl-ply 9.5-cm x 19-cm gauze pateh secured with paper tape and overwrapped with Saran Wrap<0 and Elastoplast® tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: after the 24-hour exposure period
SCORING SYSTEM: similar to the OECD scoring system (at least for erythema and edema; see below)
- Erythema: 0, No erythema; 1, Very slight erythema (barely perceptible); 2, Well-defined erythema; 3, Moderate to severe erythema; 4, Severe erythema (beet redness) to slight eschar formation (injuries in depth).
- Edema: 0, No edema; 1, Very slight edema (barely perceptible); 2, Slight edema (edges are well defined by definite raising); 3, Moderate edema (raised approximately 1 mm); 4, Severe edema (raised approximately 1 mm and extending beyond area of exposure).
- Atonia: 0, None; 1, Slight (slight impairment of elasticity); 2, Moderate (slow return to normal); 3, Marked (no elasticity);
- Desquamation: 0, None; 1, Slight; 2, Moderate (scales and flakes); 3, Marked (pronounced flaking with denuded areas).
- Coriaceousness: 0, None; 1, Slight (decrease in pliability); 2, Moderate (leathery texture); 3, Marked (tough and brittle).
- Fissuring: 0, None; 1, Slight (definite cracks in epidermis); 2, Moderate (cracks in dermis); 3, Marked (cracks with bleeding)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-72- hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: Erythema scores in the 500 and 1000 mg/kg bw dose levels remain at 4 at the end of the observation period with echar formation and possible necrotic areas
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1-14 days
- Max. score:
- 4
- Remarks on result:
- other: see table 1
- Irritant / corrosive response data:
- Based to the gravity of the erythema scores, as well as crusted areas, eschar, discoloration of the underlying muscle and necrosis, and although the treatment period was 24 hours instead of 4 hours and the coverage of test sites occlusive instead of semi-occlusive, the test substance should be considered corrosive to the rabbit skin (worst case consideration giving the 24 hours treatment and the occlusive coverage of test sites; R34 according to the EU and Category 1C according to GHS).
- Other effects:
- All animals showed eschar formation (generally from day 3 to the end) or possible necrotic areas (generally at day 1). At necropsy, the treated skin of each animal was observed to be variable dark-brown or red, with or without crusted areas. The treated skin was also thickened in some animals. The underlying muscle in some animals was also dark-brown or tan. These findings are attributed to the irritation/injury caused by the test material.
Any other information on results incl. tables
Table 1: Individual dermal irritation observation
Test group |
Sex |
Observation |
Scores |
|
Mean 1-3 days |
Day 14 |
|||
500 mg/kg bw |
First male |
Erythema |
4 |
4 |
Edema |
2 |
1 |
||
Second male |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Third male |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fourth male |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fifth male |
Erythema |
4 |
1.5 |
|
Edema |
1.5 |
1 |
||
First female |
Erythema |
4 |
4 |
|
Edema |
3 |
1 |
||
Second female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Third female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fourth female |
Erythema |
4 |
4 |
|
Edema |
2 |
1 |
||
Fifth female |
Erythema |
4 |
1.5 |
|
Edema |
2.5 |
1 |
||
1000 mg/kg bw |
First male |
Erythema |
4 |
4 |
Edema |
1.5 |
1 |
||
Second male |
Erythema |
4 |
4 |
|
Edema |
2 |
1 |
||
Third male |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fourth male |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fifth male |
Erythema |
- |
- |
|
Edema |
- |
- |
||
First female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Second female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Third female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fourth female |
Erythema |
4 |
4 |
|
Edema |
1.5 |
1 |
||
Fifth female |
Erythema |
4 |
1.5 |
|
Edema |
2 |
1 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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