Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-668-4 | CAS number: 488-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (no guideline stated), male/female rats: LD50 = 4300 mg/kg bw
Dermal (no guideline stated), rabbits: LD50 > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- June 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 2 page summary available, but study not done to guideline and not GLP.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The limits of confidence were determined by the method of Litchfield and Wilcoxon.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3500 mg/kg, 4000 mg/kg, 4500 mg/kg
- No. of animals per sex per dose:
- 3500 mg/kg = 9
4000 mg/kg = 9
4500 mg/kg = 10 - Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 300 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
LD50 = 4300 mg/kg
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Single page study summary
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No method stated
- GLP compliance:
- not specified
- Test type:
- other: no method stated
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 approximately 5000 mg/kg
- Executive summary:
LD50 approximately 5000 mg/kg
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 300 mg/kg bw
- Quality of whole database:
- The available information comprises adequate studies used in a Weight-of-Evidence approach. Although the reliability of each study cannot be determined (Klimisch score 4), the results are consistent and are thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5 of Regulation (EC) No. 1907/2006. In fact, both studies were conducted with rats of both genders; in the study reported by Givaudan, a LD50 value of 4300 mg/kg bw was reported, whereas in the study by Moreno, the LD50 is reported as approx. 5000 mg/kg bw. The most sensitive value was retained for assessment of the acute oral toxicity of the compound.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/ kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: Diarrhea in 1 animal on day 14.
- Gross pathology:
- Necropsy findings routine
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 >5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate study. Although the reliability of the study cannot be determined (Klimisch score 4), the study conduct basically fulfills the standard requirement of a guideline study, and thus the findings are considered reliable data for assessment of the acute dermal toxicity of the compound. The data are therefore considered sufficient to fulfil the standard information requirements set out in Annex VIII, 8.5 of Regulation (EC) No. 1907/2006.
Additional information
Two studies investigating the acute oral toxicity of the registered substance are available. As for both studies only short summaries are available, their reliability cannot be assigned (Klimisch score 4). However, the results obtained are consistent and indicate a low acute toxicity after oral exposure. Both studies are therefore taken into account by means of a Weight-of-Evidence approach.
In the first study (Givaudan, 1971; no guideline stated; no GLP), groups of male and female Wistar rats were dosed with the test substance by oral gavage. Doses applied were 3500 mg/kg bw (5m/4f), 4000 mg/kg bw (4m/5f) and 4500 mg/kg bw (5m/5f). Mortalities occurred as follows: In the low and mid dose groups, 1/9 animal was found dead after 6 h and 2/9 animals died within 24 h post application, respectively. Therefore, 3/9 (33%) animals died during the course of the study at each of these 2 dose levels. In the high dose group 4/10 animals died in the first 6 h after application and 2/10 within 24 h, totalling 6/10 (60%) treatment-related mortalities. The LD50 value was graphically determined to be 4300 mg/kg bw.
The finding of the first study is supported by another investigation of the acute oral toxicity (Moreno, 1977; no guideline stated; no GLP). 10 rats (no further details provided in study summary) were dosed with 5000 mg/kg bw and observed for 14 days after treatment. After application, all animals were comatose for 3 h. 4/10 animals died on day 1 and 1/10 on day 2. Hence, the total number of mortalities observed was 5/10 (50%). In conclusion, the LD50 in this study was determined to be approx. 5000 mg/kg bw
In addition to the acute oral toxicity, the acute dermal toxicity has also been investigated (Moreno, 1977; no guideline stated; no GLP). Again, only a short summary is available and hence the reliability of the study cannot be assessed (Klimisch score 4). 10 rabbits (no further details provided in study summary) were treated with 5000 mg/kg bw of the test substance and observed for 14 days. No mortalities occurred. Clinical signs observed were diarrhea in 1/10 on day 14. The dermal LD50 was therefore established to be > 5000 mg/kg bw.
With regard to Annex VIII, Item 8.5, Column 2, of Regulation (EC) No. 1907/2006 (REACH) performing an acute inhalation toxicity study with cis-Jasmone is not necessary. Studies in addition to the oral route (as required in Annex VII, 8.5.1.) shall be provided for at least one other route. The choice for the second route will depend on the nature of the substance and the likely route of human exposure. Since testing of the acute dermal toxicity has been chosen as the second route of exposure, all information requirements of Annex VIII, Item 8.5, are fulfilled.
Conclusion on acute toxicity
In two independent investigations of the acute oral toxicity and one study on acute dermal toxicity, cis-Jasmone exhibited a very low acute toxicity as indicated by LD50 values well exceeding the criteria for classification and labelling according to Regulation (EC) No. 1272/2008 (CLP) of > 2000 mg/kg bw.
Justification for classification or non-classification
The available data on acute oral and dermal toxicity are suitable to derive a classification and labelling. The available data do not meet the criteria for classification according to Regulation (EC) No. 1272/2008 (CLP) and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.