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Diss Factsheets
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EC number: 231-116-1 | CAS number: 7440-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, follows a standard operating procedure, available as an unpublished report, reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Standard Operating Procedure (SOP) prepared by Eurometaux on November 2010
- Deviations:
- no
- Principles of method if other than guideline:
- A bio-accessibility testing study has been designed to assay the metal release of Platinum compounds in gastric synthetic media. Metals or metallic compounds are subjected to a media that mimic gastric juice, in terms of pH and body temperature (pH 1.5 and 37 °C), for an exposure time of 1 hour with agitation. Then the compounds are incubated for another hour without agitation, before aliquots are taken, filtered and bio-accessible metal quantified by ICP-MS.
- GLP compliance:
- no
Test material
- Reference substance name:
- Platinum
- EC Number:
- 231-116-1
- EC Name:
- Platinum
- Cas Number:
- 7440-06-4
- Molecular formula:
- Pt
- IUPAC Name:
- platinum
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Platinum
- Substance type: powder
- Physical state: solid
- Analytical purity: >99.98 % w/w
- Purity test date: 19/04/2010
- Lot/batch No.: REF 2702/PTS 532
- Other: Particle size distribution and specific surface area (BET analysis) values were taken from: Fraunhofer IKTS report N° 4198_4208_4214_4216 of 12.11.2012.
- d50 = 286.262 µm (50th percentile of the particle size cumulative distribution as measured by volume)
- d90 = 810.924 µm (90th percentile of the particle size cumulative distribution as measured by volume)
- BET = 0.08 m2/g
Constituent 1
Results and discussion
Any other information on results incl. tables
Table 1. Platinum powder 2 hours bio-elution test in gastric mimetic fluid: Platinum released from blanks and samples at pH 1.5 ( 200 mg/L mass loading), were recorded before the sample was added and after 2 hours of incubation. The results are reported in µg/L and µg/g.
|
Gastric test parameters |
Vessel 1 |
Vessel 2 |
Vessel 3 |
Platinum, µg/L |
Platinum, µg/g |
||||||
Blanks |
Time, hr |
Temp., °C |
O2,mg/L |
pH |
R1 |
R2 |
R3 |
Mean, µg/L |
St. Dev. |
CV, % |
Mean, µg/g |
CV, % |
|
Before |
37.0 |
6.5 |
1.50 |
BDL |
BDL |
BDL |
- |
- |
- |
- |
- |
|
2 |
37.0 |
6.5 |
1.54 |
BDL |
BDL |
BDL |
- |
- |
- |
- |
- |
Pt powder |
Time, hr |
Temp., °C |
O2,mg/L |
pH |
R1 |
R2 |
R3 |
Mean, µg/L |
St. Dev. |
CV, % |
Mean, µg/g |
CV, % |
|
Before |
37.0 |
6.5 |
1.50 |
BDL |
BDL |
BDL |
- |
- |
- |
- |
- |
|
2 |
37.0 |
6.5 |
1.52 |
0.25 |
0.39 |
0.45 |
0.36 |
0.101 |
28 |
1.79 |
28 |
CV: corresponds to the coefficient of variation between vessels (the ratio between the standard deviation and the mean of metal released).
BDL: Below detection limit.
Table 2. Summary of metals solubility from Platinum powder sample; submitted to bio-elution tests in synthetic gastric media. Metal release from the bio-elution tests is reported, as percentage of solubility, after 2 hours of incubation in gastric fluid. SD = Standard Deviation, calculated from the 3 measurements performed to the 3 replica vessels.
Sample |
% solubility in gastric fluid |
|
2h |
SD |
|
Platinum powder |
2x10-4 |
1x10-4 |
Table 3. Results of the metal release per surface area exposed to the medium. The ratio between metal released in the bio-elution test, expressed in µg/g, and the specific surface area in m2/g are presented for Platinum powder.
Sample |
Metal release in gastric fluid [µg/m2] |
2 h |
|
Platinum powder |
22.4 |
The control standards used to assure the quality of the measurements obtained with ICP-MS, demonstrated an adequate stability and accuracy of the instrument during the metal quantification of the bio-elution samples. All the QC samples showed metal concentration measurements in the range of 20% around the certified value of the standards; criterion used to assure the quality of the measurements.
Applicant's summary and conclusion
- Conclusions:
- Platinum powder showed solubility of 2x10-4 % after 2 hours in gastric juice. After incubation in gastric juice, 0.36 µg/L of Pt (1.79 µg/g) was released from samples after 2 hours.
- Executive summary:
A study to estimate metal bio-accessibility for Platinum powder in synthetic gastric juice was performed following Standard Operating Procedure (SOP, Eurometaux, November 2010).
The test item was subjected to a media that mimic gastric juice, in terms of pH and body temperature (pH 1.5 and 37 °C), for an exposure time of 1 hour with agitation. Then the compounds are incubated for another hour without agitation, before aliquots are taken, filtered and bio-accessible metal quantified by ICP-MS.
Platinum powder showed solubility of 2x10 -4 % after 2 hours in gastric juice. After incubation in gastric juice, 0.36 µg/L of Platinum (1.79 µg/g) was released from samples after 2 hours.
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