Registration Dossier
Registration Dossier
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EC number: 285-080-7 | CAS number: 85029-55-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 06 November 2015 to 26 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Name: TEPA C8-10 FA
Physical state: Brown liquid
Sponsor batch: BBD 02611V1-1.step
Purity: 94 %
Arrival date: 13 November 2015
Expiry date: 6 December 2017
Storage conditions: Room temperature (15 to 30°C) - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.38 - 3
- Temp.:
- 25 °C
- Conclusions:
- It was concluded that there were three components with a mean Log Pow 0.3*, and five components with mean Log Powvalues from -0.39 to 3.09.
- Executive summary:
A total of eight peaks were identified as attributable to TEPA C8-10 FA. The first three peaks had retention times of ca 1.4, 1.7 and 1.9 minutes, which were less than that of formamide and therefore cannot be quantified. A fourth peak had a retention time between that of formamide and 2-butanone (ca 2.5 to 3 minutes), at ca 2.8 minutes. the log Pow values of these first four perks were therefore reported as less than the log Pow of 2-butanone which is 0.30. There were a further four peaks that were between 2-butanone and DDT and could therefore be directly quantified from the graphs in Figure 1 and Figure 2.
It was therefore concluded that there were four components with a mean log Pow < 0.30, and four components with mean Log Pow values from 0.38 to 3.09.
Reference
Description of key information
Partition coefficient was estimated by the HPLC simulation method using isocratic elution. The procedure conformed to those outlined in EU Directive 440/2008/EEC Method A8 and OECD Guideline 117.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.2
- at the temperature of:
- 25.2 °C
Additional information
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