Registration Dossier
Registration Dossier
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EC number: 200-891-8 | CAS number: 75-68-3
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
The substance caused hypotension in dogs and monkeys when administered for 5 minutes at concentrations up to 20%. In dogs, this was accompanied by tachycardia, an increase in pulmonary resistance and a decrease in pulmonary compliance. In monkeys the most characteristic effect was a depression of contractility with a fall in aortic blood pressure. In addition, respiratory stimulation upon 5 minutes exposure to concentrations up to 20% and myocardial depression at concentrations of 5-10% were observed.
Additional information
In dogs the substance caused hypotension when administered for 5 minutes at a concentration of 20%. There were accompanying statistically significant tachycardia, an increase in pulmonary resistance and a decrease in pulmonary compliance. The substance produced bronchoconstriction which was not abolished by the administration of atropine.
In rhesus monkeys the substance also caused hypotension, but also respiratory stimulation upon 5 minutes exposure to concentrations up to 20%. The substance did not induce arrhythmia or tachycardia even when inhaled at concentrations as high as 10 or 20%, but did induce myocardial depression when inhaled at concentrations 5-10%. The most characteristic effect was a depression of contractility with a fall in aortic blood pressure.
Exposure of beagle dogs to concentrations of 1-chloro-1,1-difluoroethane from 5 to 20 % (v/v) for 5 min, followed by a challenge injection of epinephrine, indicated that 1-chloro-1,1-difluoroethane is capable of sensitizing the canine heart to epinephrine. A threshold for cardiac arrhytmia induction was established to correspond to 25000 ppm (102 mg/l), while EC50 was established to be ca. 50000 ppm (205 mg/l).
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