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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 453-460-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 13 Mar - 21 Apr 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets basic scientific principles. Study report without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Method of Marzuli and Maibach.Induction-phase: The test-substance was applied to the upper back of 56 volunteers under occlusive conditions for 48 h, 3 times a week for 3 weeks and graded for skin reactions. After a two weeks resting period, the challenge patches were applied to previously treated and unexposed sites for 48 h and analysed for dermal reactions after 48, 72 and 96 h.
- GLP compliance:
- no
- Remarks:
- GCP compliant
Test material
- Reference substance name:
- 84418-63-3
- Cas Number:
- 84418-63-3
- IUPAC Name:
- 84418-63-3
- Details on test material:
- - Name of test material (as cited in study report): pentaisononanoate de dipentaerythritol- Analytical purity: no data- Lot No: 05078603
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- confirmed, but no further information available
- Subjects:
- - Number of subjects exposed: 56- Sex: male and female- Age: 18-69
- Clinical history:
- - History of allergy or casuistics for study subject or populations: No- Exposure history: No
- Controls:
- No
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test) ADMINISTRATION- Type of application: occlusive- Concentrations: applied pure- Volume applied: 0.2 mL- Testing/scoring schedule: Occlusive patches with 0.2 mL of test substance for 48 h 3 times a week for 3 weeks. Following a two weeks resting period, the challenge patches (pure test substance) were applied to previously treated test sites on the back (original) and to previously unexposed newly defined sites (virgin) for 48 h. Scoring was performed after each application (induction scores) and after patch removal (48 h) and at 72 and 96 h after challenge.EXAMINATIONS- Grading/Scoring system: Accounting for erythema and edema formation according to the method of Marzuli and Maibach:- = no reaction? = minimal or doubtful response, slightly different from surrounding normal skin+ = definite Erythema, no edema++ = definite erythema, definite edema+++ = definite erythema, definite edema and vesiculation
Results and discussion
- Results of examinations:
- SYMPTOMS- Frequency, level, duration of symptoms observed: One individual showed definite erythema but no edema 72 h and 96 h after challenge. Two other subjects had minimal or doubtful, reversible, reactions 48 h or 72 h after challenge.NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION- Number of subjects with positive reactions: 1- Number of subjects with negative reactions: 53- Number of subjects with equivocal reactions: 2- Number of subjects with irritating reactions: 0
Applicant's summary and conclusion
- Conclusions:
- Not sensitising, not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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