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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
Qualifier:
according to guideline
Guideline:
EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(5α)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one
EC Number:
260-887-7
EC Name:
(5α)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one
Cas Number:
57664-96-7
Molecular formula:
C17H19NO4
IUPAC Name:
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
Test material form:
solid
Details on test material:
brown color

Study design

Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, domestic (adaptation not specified)
Duration of test (contact time):
<= 28 d
Initial test substance concentration
Initial conc.:
<= 102.7 mg/L
Based on:
test mat.
Parameter followed for biodegradation estimation
Parameter followed for biodegradation estimation:
O2 consumption
Details on study design:
Noroxycodone was investigated for its ready biodegradability in a manometric respirometry test over a period of 28 days.
The reference item sodium benzoate (control) was tested simultaneously under the same conditions as the test item.
Other information: temperature at 22°C, darkness conditions, climatised chamber, pH of 7.6 (start test) and 7.5-7.7 (end test), vehicule composed of reconstituted water (pure water + salts)
Reference substance
Reference substance:
benzoic acid, sodium salt

Results and discussion

% Degradation
Key result
Parameter:
% degradation (O2 consumption)
Value:
<= 0
Sampling time:
28 d
Details on results:
The mean biodegradation at test end of the test after 28 days was 0% (THOD(NH4), ThOD(NO3)). Therefore, Noroxycodone is considered to be not readily biodegradable.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Interpretation of results:
not readily biodegradable
Conclusions:
Based on the experimental results, Noroxycodone is considered to be not readily biodegradable.