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Diss Factsheets
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EC number: 202-431-1 | CAS number: 95-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Two subacute oral toxicity studies in rats were performed with o-aminophenol. In study 1 with treatment over 30 days at daily doses 0, 20, 80, 320 mg/kg bw, none of the three tested doses could be considered as a NOAEL. In study 2 with doses of 0, 2. 5 and 15 mg/kg bw/d, a NOAEL of 5 mg/kg bw/d was derived based on the thyroid weight changes observed.
Both subchronic toxicity studies are considered to be inconclusive.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 5 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Two subacute oral toxicity studies in rats were performed with o-aminophenol. In study 1 with treatment over 30 days at daily doses 0, 20, 80, 320 mg/kg bw, none of the three tested doses could be considered as a NOAEL. Increased liver and kidney weight as well as mottled kidneys and renal tubular lesions were observed in the mid and high dose group. In addition, an increase in blood urea nitrogen and in urinary proteins were seen in the high dose group. In study 2 with doses of 0, 2. 5 and 15 mg/kg bw/d, a NOAEL of 5 mg/kg bw/d was derived based on the thyroid weight changes observed. Reduced body weight in the high dose group and in females of the mid and low dose group was also abserved.
A three-month oral toxicity study was performed in rats. As only a single dose level of 50 mg/kg bw/d was tested, the results are inconclusive. The value of the 13-week dermal toxicity study of a hair dye formulation in rabbits is limited due to the low dose applied (topical application of an oxidation hair-dye mixture with a final concentration of 0.15%). No study on sub-chronic toxicity according to the Notes of Guidance was submitted. Both subchronic toxicity studies are considered as inconclusive due to single dose testing and inappropriate dose level.
Repeated dose toxicity: via oral route - systemic effects
(target organ) urogenital: kidneys
Justification for classification or non-classification
These data from secondary sources are not suiteable to derive a classification or labelling of the substance according the dangerous substance directive (67/548/EEC) or the Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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