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EC number: 219-588-7 | CAS number: 2469-55-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Ready biodegradability [3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine]: Not readily biodegradable.
Ready biodegradability [3-aminopropyldimethysilanol]: Not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
There are no reliable ready biodegradation data available for 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine (CAS 2469-55-8), therefore good quality data for two structurally-related substances, hexamethyldisiloxane (CAS 107-46-0) and 3-aminopropyltriethoxysilane (CAS 919-30-2), have been read across. All three substances hydrolyse in the time scale of a standard 28-day ready biodegradability test and have silanol hydrolysis products related to those of the registration substance.
3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine hydrolyses to 3-aminopropyldimethysilanol. Hexamethyldisiloxane hydrolyses to trimethylsilanol. 3-Aminopropyltriethoxysilane hydrolyses to 3-aminopropylsilanetriol. 3-Aminopropyltrimethoxysilane also produces ethanol as a by-product. Ethanol is readily biodegradable (OECD 2004).
3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine and 3-aminopropyltriethoxysilane are within an analogue group of substances within which, in general, there is no evidence of any significant biodegradation once hydrolysis and subsequent biodegradation of alkoxy/acetoxy groups has been taken into account. These source data for read across are informative in respect of the Si-CCCNH3 groups present in the registration substance structure.
Hexamethyldisiloxane (CAS 107-46-0) is in the siloxane analogue group. In general, siloxane substances exhibit no evidence of any significant biodegradation. These source data for read across are informative in respect of the Si-CH3 groups present in the registration substance structure.
It is therefore considered valid to read-across the results for hexamethyldisiloxane (CAS 107-46-0) and 3-aminopropyltrimethoxysilane (CAS 919-30-2) to fill the data gap for the registered substance. The table below presents ready biodegradation data for the identified read-across substances.
Additional information is given in a supporting report (PFA, 2013f) attached in Section 13.
Table: Ready biodegradation data available for read-across substances
CAS |
Name |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 days (%) |
Guideline |
Test type |
Klimisch code |
Expected % biodegradation assuming only alkoxy/acetoxy parts biodegrade |
Expected % biodegradation assuming only silanol side-chain parts biodegrade |
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for[1] |
Study ID Code[2] |
919-30-2 |
3-aminopropyltriethoxysilane |
Yes |
76% |
OECD 306 |
DOC |
1 |
67 |
33 |
9 |
5.2.161 |
000107-46-0 |
Hexamethyldisiloxane |
No |
2% |
OECD 301C |
BOD |
1 |
n/a |
n/a |
2 |
5.2.088 |
[1] The negative values in this column are where the biodegradation rate observed in the test is less than that expected assuming only alkoxy/acetoxy parts biodegrade. This could be due to low solubility of parent substance or low rates of hydrolysis. These values should in effect be considered as zero.
[2] This is a unique internal ID code which can be used to identify the reference for the study.
In the study with hexamethyldisiloxane (CAS 107-46-0), 2% or 20% biodegradation was observed in 28 days (based on O2 consumption and chemical analysis respectively). Hexamethyldisiloxane hydrolyses within the timescale of the ready biodegradation study to trimethylsilanol. The study was conducted according to OECD 301C and is considered reliable. The study is considered to be reliability 1 (reliable without restrictions).
Two studies are available with 3-aminopropyltriethoxysilane (CAS 919-30-2); in the key study, 76% biodegradation was observed in 28 days (based on O2 consumption). 3-Aminopropyltriethoxysilane hydrolyses within the timescale of the ready biodegradation study to 3-aminopropylsilanetriol and ethanol. The biodegradation observed in the studies is mainly attributable to the biodegradation of the ethanol hydrolysis product. Ethanol is readily biodegradable (OECD, 2004). No significant biodegradation is expected for the silanol hydrolysis product 3-aminopropylsilanetriol. The study was conducted according to OECD 306 and is considered reliable. The study is considered to be reliability 1 (reliable without restrictions).
Both studies are used as weight of evidence for the conclusion on ready biodegradability of 3,3'-(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bispropylamine (CAS 2469-55-8) (and its hydrolysis products).
References:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 19-22 October 2004, Ethanol, CAS 64-17-5.
PFA, 2013f, Peter Fisk Associates, Biodegradation Main Analogue Group report, PFA.300.005.007
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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