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Reaction mass of bis(polysubstituted hexanoic acid) bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) diphosphate and bis(polysubstituted hexanoic acid) 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl phosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen diphosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) phosphate and polysubstituted hexanoic acid 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl hydrogen phosphate
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- Remarks:
- Conducted according to guideline in effect at the time of study conduct.
- GLP compliance:
- yes
Test material
- Reference substance name:
- TLF-11073
- IUPAC Name:
- TLF-11073
- Details on test material:
- - Purity: 22.82% solids in water
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Laboratory culture: A synthetic sewage feed was prepared by dissolving the following ingredients in dechlorinated water to a final volume of 500 mL. It had a pH of 7.21.
7.998 g Peptone
5.499 g Meat extract
1.504 g Urea
0.356 g NaCl
0.2007 g CaCl2.2H2O
0.1010 g MgSO4.7H2O
1.403 g K2HPO4
- Preparation of inoculum for exposure: At time 0 hour, 16 mL of synthetic sewage feed was diluted to 284 mL with dechlorinated tap water.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- Hardness:
- Not reported
- Test temperature:
- 22.1-23.1°C
- pH:
- 6.24 for the microbial inoculum
- Dissolved oxygen:
- Not reported
- Nominal and measured concentrations:
- 1000 mg (solids)/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 1000 mL glass flask; test solutions were transferred to 300-mL Biological Oxygen Demand (BOD) glass bottles for Dissolved Oxygen (DO) determinations
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: Glass; 1000 mL headspace; 500 mL fill volume
- Aeration: Compressed air at a flow rate between 2-5 liters per minute at room temperature
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 1 for abiotic control; 3 for reference substance
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water was prepared by aerating tap water for a minimum of 48 hours.
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Photoperiod: 3 h exposure
- Light intensity: not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Oxygen consumption rates for 3 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable; the highest concentration required by the guideline was tested. - Reference substance (positive control):
- yes
- Remarks:
- (3,5-Dichlorophenol (purity 99.5%; nominal concentrations 3.2, 10, and 32 mg/L)
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: solids
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- No significant difference (p = 0.05) in the microbial respiration of test systems with the test substance at 1000 mg solid/L compared to the positive controls.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: The effect concentration at which 50% inhibition occurred (EC50) was approximately 17.8 mg/L. The maximum difference between the respiration rates of the three positive controls was less than 10%. - Reported statistics and error estimates:
- The 3-hour EC50 (Effective Concentration that inhibits respiration by 50%) and its 95% confidence limit were calculated by standard statistical methods.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
- Conclusions:
- The 3-hour EC50 >1000 mg solids/L.
- Executive summary:
The test substance was tested for respiration inhibition using the Activated Sludge, Respiration Inhibition test according to OECD Guideline 209 in the version dated July 22, 2010. The biological system was secondary activated sludge from the Elkton, Maryland (U.S.A) Publicly-Owned Treatment Works (POTW).
For the determination of the inhibitory behaviour of the test substance, activated sludge from the aeration tank of a municipal sewage treatment plant was exposed to the test substance at 1000 mg solids/L nominal concentration in triplicate. For the reference substance, 3,5-dichlorophenyl, activated sludge was exposed at 3.2, 10, and 32 mg/L nominal concentrations. After a 3-hour incubation period, the inhibition of the respiration rate of the activated sludge was determined in comparison to a test solution without any test or reference substance (positive control).
Under the conditions of the test, there was no significant difference in the microbial respiration of test systems with the test substance at 1000 mg solids/L compared to the positive controls. The Effective Concentration of the reference substance, 3,5-dichlorophenol, at which 50% inhibition occurred (EC50) was calculated as approximately 17.8 mg/L. The maximum difference between the respiration rates of the three positive controls was less than 10%. The test substance did not inhibit microbial respiration at a nominal concentration of 1000 mg solids/L. The test is valid.
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