9-[2-(2-methoxyethoxy)ethoxy]-9-[3-(oxiranylmethoxy)propyl]-2,5,8,10,13,16-hexaoxa-9-silaheptadecane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

This study was conducted between 24 June 2016 and 18 December 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

EC No. 440/2008 30 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 July 1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

> 95 vol%

Conc. based on:

test mat.

Loading of aqueous phase:

174 000 mg/L

Temp.:

20 °C

pH:

ca. 7

Key result

Water solubility:

19 136 147 mg/L

Temp.:

20 °C

pH:

7

Details on results:

The standard EC method A6 and OECD method 105 was not applicable to this test item due to the high indeterminable saturation levels produced. It was therefore not possible to prepare samples at five times the saturation level as recommended in the guidelines. No analysis could be performed for the main test due to the high solubility producing unfilterable mixtures. Therefore the water solubility was determined based on visual inspection.
Due to the fast hydrolysis of the test item, a short shake flask was used to confirm the result. The 1 hour timing provided the same result as the 72 hour shake at elevated temperatures. Hydrolysis at pH 7 shows that > 90% of the test item would be remaining with a 1 hour shake at 20 °C and time for the observations.

The results of the definitive test for the water solubility are shown in the table below

Table: Results of Definitive Water Solubility Tests

Concnetration (%w/w)	Observation
4.96	Clear colorless solution free from any excess test item
49.8	Clear colorless solution free from any excess test item
74.8	Clear colorless solution free from any excess test item
89.8	Clear colorless solution free from any excess test item
95.0	Clear colorless solution free from any excess test item
95.0 (1 hour shake)	Clear colorless solution, soingle phase, free from any excess test item

Water solubility greater than 95% w/w at 20.0 ± 0.5 ºC

Conclusions:

The water solubility of the test item has been determined to be greater than 95% w/w of solution at 20.0 ± 0.5 ºC.

Executive summary:

The general physico-chemical properties of 9-[2-(2-METHOXYETHOXY)ETHOXY]-9-[3(OXIRANYLMETHOXY)PROPYL]-2,5,8,10,13,16-HEXAOXA-9-SILAHEPTADECANE have been determined.  

Water Solubility.

Greater than 95% w/w of solution at 20.0 ± 0.5 °C, using the adapted flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

The water solubility was greater than 95% w/w of solution at 20.0 ± 0.5 °C this was considered to be equal to an aqueous loading of 174000 mg/L, using the adapted flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Key value for chemical safety assessment

Water solubility:

174 000 mg/L

at the temperature of:

20 °C