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Diss Factsheets
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EC number: 944-341-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- June 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented guideline study in compliance with GLP
- Justification for type of information:
- A substantial body of evidence exists that the toxicity profiles of chelates depends mainly on metal ion, its affinity to this metal, and their ability to supply or to sequester it from the body/environment. The source substance has the same chelating agent as in a target substance (CaNa2IDHA). The only difference between the target and the source substance is presence of calcium (Ca) cation instead Fe3+ cations. As calcium is an essential macro element required by all forms of life, is considered not to influence the toxicological activity.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- 5 ml of acetonitrile was added to 5 ml of water sample (control sample, sample contaminated with test material or fortified with standard solution) in Erlenmeyer flask. Contents of the flask was mixed throughly and applied to the chromatographic column in volume of 20 µL. Solutions of Fe(III)IDHA in concentration below 2 mg/L were injected to the chromatographic column without dissolving in acetone.
- Vehicle:
- no
- Details on test solutions:
- In the study test material was used in one concentration (limit test) - 100 mg/L. Concentration of test material was prepared by weighing of 10 mg of test material, precise mixing in 100 ml of Elendt water used in test, and then introducing to the test system.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Animals Daphnia manga used in experiments were taken from own laboratory culture of Institute of Organic industry, Branch Pszczyna. In the experiments animals in good physiological condition (checked by test with refrence substance - potassium dichromate) up to 24 hours old were used.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not reported
- Hardness:
- not reported
- Test temperature:
- 22-23oC
- pH:
- control: 7.6- 7.77
tested solution: 8.64 - 8.51 - Dissolved oxygen:
- control: 8.79-8.67
tested solution: 8.64-8.51 - Salinity:
- not applicable
- Nominal and measured concentrations:
- nominal concentration: 100mg/L
measured concentration:
t0= 101.06 mg/L
t48h = 94.4 mg/L - Details on test conditions:
- The test environmental and the dilution medium used for preparing the test material solution was standarized elendt water M7, the same like used in culture. The test was run in plastic test containers of 100 mL capacity. Before test start Elend water was aerated for 30 min. Test concentrations as well as control was set up in four replicates. The volume of the test material solution in every replicate was 25 mL. Five individuals of Daphnia manga were used per each replicate (i.e. 20 animals per concentration). Therefore there was 5 mL of test solution per each animal (acc. to OECD gudeline should be at least 2 mmL). The test was run for 48 hours in natural photopheriod. The test was run in static manner. Animals were not fed during the test and the temperature was maintained in range 22-23oC. At the begining of the test and after 48 h pH values and content of dissolved oxygen were measured, the same measurements were performed for fresh solutions (pH-Oxi-metr inoLAB Level 3, WTW Germany).
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- >= 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Details on results:
- All validity criteria were met:
- mortality and immobilization of tested animals in control was 0%
- concentration of dissolved oxygen was 8.67 mg/L after 48h - Results with reference substance (positive control):
- Resultsts for K2Cr2O7:
EC50(24h) > 3.2 mg/L
EC50(48h) = 1.13 mg/L (0.93-1.37 mg/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- Median concentration causing 50% immobilization of Dapnia manga population (EC50) after 48h was above 100 mg/L, EC0 after 48h is above or equal 100 mh/L, and EC100 after 48H is above 100 mg/L.
- Executive summary:
The toxicity assessment of Fe(III)IDHA was performed according to OECD Guideline 202 and test method C.2 and in compiance with GLP (OECD, 1997). The aim of the study was evaluation of acute toxicity to Daphnia manga exposed to a range of concentrations of the test material (determination of EC50, EC0 and EC100 in mg/L after 24h and 48h exposure).
The test material was used in only one concentration (limit test) - 100 mg/L. Because of no mortality was observed in tested Daphnia population the EC50/48h value is above 100 mg/L, EC0 value is equel or above 100 mg/L, and EC100 value is above 100 mg/L.
Reference
Description of key information
The toxicity assessment of FeNaIDHA was performed according to OECD Guideline 202 and test method C.2 and in compiance with GLP (OECD, 1997). The aim of the study was evaluation of acute toxicity to Daphnia manga exposed to a range of concentrations of the test material (determination of EC50, EC0 and EC100 in mg/L after 24h and 48h exposure).
The test material was used in only one concentration (limit test) - 100 mg/L. Because of no mortality was observed in tested Daphnia population the EC50/48h value is above 100 mg/L, EC0 value is equel or above 100 mg/L, and EC100 value is above 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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