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Diss Factsheets
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EC number: 204-072-6 | CAS number: 115-21-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Introduction
There are no in vivo data on the toxicokinetics of trichloro(ethyl)silane. The following summary has therefore been prepared based on the physicochemical properties of the substance itself and its hydrolysis products. Trichloro(ethyl)silane is a moisture-sensitive, volatile liquid. Rapid hydrolysis occurs, producing ethylsilanetriol and hydrogen chloride. Exposure may occur via the inhalation or dermal routes. Relevant inhalation exposure would be to the hydrolysis products (hydrolysis would occur rapidly when inhaled, even if a mixture of parent and hydrolysis products were present in air). The substance would also hydrolyse rapidly in contact with moist skin. The resulting HCl hydrolysis product would be severely irritating or corrosive. At sufficiently high concentrations, subsequent condensation of the silanol hydrolysis product can occur, resulting in formation of siloxanes.
Absorption
Oral
Significant oral exposure is not expected for this corrosive substance.
Dermal
The molecular weights of the parent and hydrolysis products favour absorption across the skin. However, the very high water solubility (1E+06 mg/l) and low predicted log Kow(-1.9) of the hydrolysis product, ethylsilanetriol, suggest that it is too hydrophilic to cross the lipid rich stratum corneum. Therefore dermal uptake is likely to be low. Since the other hydrolysis product, HCl, is corrosive to the skin, damage to the skin might increase penetration. There are no reliable studies to check for signs of dermal toxicity as evidence of dermal absorption.
Inhalation
The partition coefficient and high water solubility suggest that this substance is likely to be retained in the mucous of the lungs, and absorption limited. As with dermal exposure, damage to membranes caused by the corrosive nature of the other hydrolysis product, HCl, might enhance the uptake. Acute inhalation studies showed local signs but no definite systemic effects.
Distribution
All absorbed material is likely to be in the form of the hydrolysis products, ethylsilanetriol and hydrogen chloride. Ethylsilanetriol is a small molecule, and is likely to be widely distributed, but its hydrophilic nature will limit its diffusion across membranes (including the blood-brain and blood-testes barriers) and its accumulation in fatty tissues. Hydrogen and chloride ions will enter the body’s natural homeostatic processes.
Metabolism
Trichloroethylsilane is rapidly hydrolysed to ethylsilanetriol and hydrogen chloride in the presence of moisture. Most if not all of this will have occurred before absorption into the body. There is no data regarding the metabolism of ethylsilanetriol. Genetic toxicity tests in vitro using either trichloro(ethyl)silane or the related substance trichloro(methyl)silane showed no clear, observable differences in effects with and without metabolic activation.
Excretion
The low molecular weight and high water solubility of ethylsilanetriol suggest that it is likely to be rapidly eliminated via the kidneys in urine. There is therefore no evidence to suggest that this substance will accumulate in the body.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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