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EC number: 206-033-9 | CAS number: 294-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-08-01 to 1984-08-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclododecane
- EC Number:
- 206-033-9
- EC Name:
- Cyclododecane
- Cas Number:
- 294-62-2
- Molecular formula:
- C12H24
- IUPAC Name:
- cyclododecane
- Details on test material:
- Cyclododecane of Hüls AG, purity ca. 99.5 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: F. Winkelmann, Borchen (Germany)
- Weight at study initiation: males 125 g, females 107 g (mean)
- Fasting period before study: 16 hours
- Diet: ad libitum, Sniff
- Water: ad libitum, tab water
- Acclimation period: 4 -8 days
- Temperature (°C): 20 °C +/- 1° C
- Humidity (%): 60 % +/- 5 %
- Air changes (per hr): 15 times
- Photoperiod (hrs dark / hrs ligh: 12 hours light/ 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: corn oil
- Details on oral exposure:
- ADMINISTRATION:
- Doses: 10000 mg/kg b.w.
- Doses per time period: 2 applications separated by 2 hours; temperature of applied substance 40-45 degree C
- Volume administered or concentration: 20 ml/kg - Doses:
- 10000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- EXAMINATIONS:
- Post dose observation period: 14 days
- Body weights: before and 1 , 7, and 14 days post dosing
- Clinical signs: observed 6 hours after treatment and thereafter daily
- Macroscopic examination at necropsy - Statistics:
- - LD50 calculation: according to Litchfield and Wilcoxon, in connection with the Gauß integral
Results and discussion
- Preliminary study:
- preliminary test was conducted with reduced number of animals but no data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- MORTALITY:
- Time of death: within 7 hours
- Number of deaths at each dose: 2/5 females, no males - Clinical signs:
- CLINICAL SIGNS: 1/2 - 2 hours post application, animals revealed pilo-erection and diuresis, later accompanied by tremor, convulsions, diarrhoea,
blood from eyes and noses, lying on back, side, or in prone position, sounds in case of contact, Straub reaction and walking on toes. Symptoms of
toxicity were visible for up to 72 hours. - Body weight:
- - Body weights: not affected
- Gross pathology:
- NECROPSY FINDINGS: Pale mucosa of stomach and gastro-intestinal tract, bright discoloration of kidney and spleen, dark spots and small blood
vessels on the liver were observed in animals that died during the study. Necroscopy at the end of the study revealed hyperemia of the intestinal
mucosa and in one animal of the forestomach. In some animals, liver and kidneys were brighter or covered with bright petechiae. - Other findings:
- no other findings
Any other information on results incl. tables
no further remarks
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Regulation EC No 1272/2008 (CLP)
- Conclusions:
- Under the conditions of this study the acute toxicity of Cyclododecane after oral application in rats is very low.
- Executive summary:
The test item Cyclododecane was applied two times, separated by 2 hours, to 5 male and 5 female Wistar rats in dose of 10.000 mg/kg bw, volume of administration was 20 ml/kg. The observation period was 14 days. Two female rats died within 7 hours after oral application of the test item. Pale mucosa of stomach and gastro-intestinal tract, bright discoloration of kidney and spleen,dark spots and small blood vessels on the liver were observed in animals that died during the study. 1/2 - 2 hours post application, animals revealed pilo-erection and diuresis, later accompanied by tremor, convulsions, diarrhoea, blood from eyes and noses, lying on back, side, or in prone position, sounds in case of contact, Straub reaction and walking on toes. Symptoms of toxicity were visible for up to 72 hours. Under the conditions of this study the acute toxicity of Cyclododecane after oral application in rats is very low.
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