N,N'-methylenediacrylamide

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August 1-2, 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-methylenediacrylamide

EC Number:

203-750-9

EC Name:

N,N'-methylenediacrylamide

Cas Number:

110-26-9

Molecular formula:

C7H10N2O2

IUPAC Name:

N,N'-methylenediacrylamide

Test material form:

solid: particulate/powder

Details on test material:

Purity: 9 9.8% w/w

Identification: N, N’-methylene-bis-acrylamide
Batch: LQ27A1696
Manufacturing date: 13 January 2016
Expiry date: 12 January 2018
Supplier: SNF SAS
Appearance: White powder
Packaging: White opaque PE flask
Quantity received: 2 x 800 g
Date of receipt 08 February 2016

Storage In darkness at room temperature

Identification number of the test item 16-033

Specific details on test material used for the study:

Identification: N,N’-METHYLENE-BIS-ACRYLAMIDE
Batch: LQ27A1696
Manufacturing date: 14 January 2016
Expiry date: 13 January 2017
Supplier: SNF SAS
Appearance: White powder
Packaging: White opaque PE flask
Quantity received: 800 g
Date of receipt: 08 February 2016

Storage In darkness at room temperature

Identification number of the test item 16-033

Study design

Analytical method:

high-performance liquid chromatography

photometric method

Results and discussion

Partition coefficient

Key result

Type:

log Pow

Partition coefficient:

-0.08

Temp.:

24 °C

pH:

>= 7.87 - <= 7.98

Any other information on results incl. tables

Partitioncoefficient results

 

TheresultsfortheN,N’-methylene-bis-acrylamideinthetwophasesaregiveninthefollowingtable:

 

Identification	Peak area ATEST	Mean peak area ATEST	Concentration after dilution (mg/L) CD	Dilutionfactor Df	Concentration before dilution (mg/L) C	Coctanol / Cwater	LogPow
16-033A8A1 Phaqdil	12632830	12575454	28.52	20	570.3	0.816	-0.088
	12518078
16-033A8A1 Phocdil	10233507	10261152	23.26	20	465.3
	10288796
16-033A8A2 Phaqdil	12748194	12730074	28.87	20	577.3	0.826	-0.083
	12711953
16-033A8A2 Phocdil	10477912	10514677	23.84	20	476.8
	10551441
16-033A8B1 Phaqdil	8582469	8574875	19.44	20	388.8	0.828	0.082
	8567281
16-033A8B1 Phocdil	7105865	7100399	16.09	20	321.9
	7094932
16-033A8B2 Phaqdil	8563772	8554513	19.39	20	387.9	0.822	0.085
	8545254
16-033A8B2 Phocdil	7013568	7030666	15.94	20	318.7
	7047764
16-033A8C1 Phaqdil	17637276	17652019	40.03	20	800.7	0.833	-0.080
	17666762
16-033A8C1 Phocdil	14755805	14696954	33.33	20	666.6
	14638102
16-033A8C2 Phaqdil	17914212	17834807	40.45	20	809.0	0.832	-0.080
	17755402
16-033A8C2 Phocdil	14841837	14835556	33.64	20	672.9
	14829274

 

Mean Log Pow = -0.08

 

Theconcentrationofthestartingwater testitem solutionwasequalto1.04g/L.Thetemperatureduringthepartitionphasewasequalto24°C±1°C.

 

ThepH of the water saturated phase before the partition was equal to 6.92 at24.0°C.

 

ThepH of the aqueous phase solutions after the partition was between 7.87 and7.98at 22.0°C.

 

Applicant's summary and conclusion

Conclusions:

The value of the n-octanol/water partition coefficient log10Pow of N,N’-methylene-bis-acrylamide was found to be -0.08 by using the shake flask method.