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EC number: 209-052-0 | CAS number: 553-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-06-29 to 1993-07-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3H)-benzofuran-2-one
- EC Number:
- 209-052-0
- EC Name:
- (3H)-benzofuran-2-one
- Cas Number:
- 553-86-6
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 2,3-dihydro-1-benzofuran-2-one
- Details on test material:
- - Name of test material (as cited in study report): 2-COUMARANONE
- Physical state: solid
- Lot/batch No.: D 2008
- Storage condition of test material: in a plastic flask, at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- other: The left flank did not receive any test substance and served as control.
- Amount / concentration applied:
- A dose of 500 mg of the test substance in its original form was applied to a 6 cm2 hydrophilic gauze patch moistened with 0.5 ml of water for injections and this was then applied to the right flank of each animals.
- Duration of treatment / exposure:
- The test substance was held in contact with the skin for 4 hours. Any residual test substance was removed by means of a compress moistened with water for injections.
- Observation period:
- Cutaneous reactions were observed approximately 1, 24, 48 and 72 hours after removal of the dressing and then daily until day 13 in order to observe their reversibility.
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 11 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Reversibility:
- fully reversible within: 13 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Reversibility:
- fully reversible within: 11 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: no signs of irritation (edema) at any time
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Other effects:
- From days 4 to 12, a dryness of the skin was observed on the treated sites of three aninals and a temporary yellow colouration in one animal (1 h - 48 h). These effects were fully reversible within 13 d. No signs of tissular lesions on the whole thickness of the skin were noted.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- As the mean scores for erythema, oedema for 2 out of the 3 animals reached the criteria values for irritation, under these experimental conditions, the test substance, 2-COUMARANONE, was considered as irritant when administered by cutaneous route in rabbits.
- Executive summary:
The potential of the test substance, 2-COUMARANONE, to induce dermal irritation was evaluated in rabbits according to O.E.C.D. (No. 404, 12th May 1981) guidelines. The study was conducted in compliance with the Principles of Good Laboratory Practice Regulations.
A single dose of 500 mg of the test substance was prepared on a moistened compress, and then applied to a 6 cm2 clipped area of the skin of 3 male New Zealand White rabbits. The test substance was held in contact with the skin for 4 hours by means of a semi-occlusive dressing. Cutaneous reactions were observed approximately 1, 24, 48 and 72 hours after removal of the dressing and then daily until day 13 in order to observe their reversibility. Any residual test substance was removed by means of a compress moistened with water for injections. The mean score of the values for erythema and oedema recorded for each animal after 24, 48 and 72 hours was calculated.
Very slight cutaneous reactions in 1 animal and marked in 2 animals were observed during at least 72 hours. These reactions consisted of an erythema (scores of 1 to 4) and an oedema (scores of 2 to 4). The erythema was reversible on day 10 and oedema on day 3. The mean scores for each animal were 1.0, 2.7 and 3.0 for erythema and 0.0, 0.7 and 1.0 for oedema. From days 4 to 12, a dryness of the skin was observed on the treated site. No signs of tissular lesions on the whole thickness of the skin were noted. On day 13, all the cutaneous reactions were reversible.
As the mean scores for erythema, oedema for 2 out of the 3 animals reached the criteria values for irritation, under these experimental conditions, the test substance, 2-COUMARANONE, was considered as irritant when administered by cutaneous route in rabbits.
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