Registration Dossier
Registration Dossier
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EC number: 233-343-1 | CAS number: 10124-56-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Sodium Metaphosphate, Sodium Trimetaphosphate, and Sodium Hexametaphosphate
- Author:
- Reviewed by the Cosmetic Ingredient Review Expert Panel.
- Year:
- 2 001
- Bibliographic source:
- International Journal of Toxicology, p 75-89.
Materials and methods
- Principles of method if other than guideline:
- Evaluated using the Illustrated Guide for Grading Eye Irritation Caused by Hazardous Substances.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium metaphosphate
- EC Number:
- 233-343-1
- EC Name:
- Sodium metaphosphate
- Cas Number:
- 10124-56-8
- Molecular formula:
- Na6O18P6
- IUPAC Name:
- hexasodium 2,4,6,8,10,12-hexaoxocyclohexaphosphoxane-2,4,6,8,10,12-hexakis(olate)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Animals weights from 1.6 to 2.1 kg
Test system
- Vehicle:
- water
- Amount / concentration applied:
- Ten milligrams of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.
Results and discussion
In vivo
Results
- Remarks on result:
- other: Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
- Executive summary:
The test was performed with 6 New Zealand White rabbits. Ten milligram of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.
The untreated eye of each rabbit served as its control. The eyes were then observed at 24, 48, and 72 hours.
Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and non remissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.
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