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Diss Factsheets
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EC number: 223-620-5 | CAS number: 3982-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-10 to 2002-08-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane
- EC Number:
- 223-620-5
- EC Name:
- 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane
- Cas Number:
- 3982-82-9
- Molecular formula:
- C28H32O2Si3
- IUPAC Name:
- 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl: CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Germany
- Age at study initiation: 6-7 weeks
- Weight at study initiation: 209-224g for males and 183-193g for females
- Fasting period before study: 16 hours
- Housing: Makrolon cages
- Diet: Standard diet for rats and mice ssniff R/ M-H V 1530, discontinued 16 hours before treatment, ad libitum
- Water: tap water, ad libitum
- Acclimation period: Five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 3
- Humidity (%): 55 ±15
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.9 ml/kg bw
- Doses:
- 2000 mg/kg bw/day
- No. of animals per sex per dose:
- Three
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: before administration and immediately, 5, 15, 30 and 60 minutes and then 3, 6 and 24 hours after administration.
- Necropsy of survivors performed: yes
- Other examinations performed: during the follow-up period ( 14 days) changes of skin and fur, eyes and mucous membranes, respiratory and the circulatory, autonomic and central nervous system, somatomotor activity as well as behaviour pattern were observed at least once per day until all symptoms subsided, thereafter each working day. Attention was also paid to possible tremor, convulsions, salivation, diarrhoea, lethargy, sleep and coma. Observations on mortality were made at least once daily. Individual body weights were recorded before administration of the substance and thereafter in weekly intervals up to the end of the study, and at death. On test day 15, all surviving animals were sacrificed, dissected and examined macroscopically. A microscopic examination of all organs that showed evident lesions was performed on all animals that survived at least 24 hours. Autopsy and macroscopic inspections of animals that died prematurely would have been conducted as soon as possible after death. - Statistics:
- No statistics carried out.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths.
- Clinical signs:
- No clinical signs of systemic toxicity.
- Body weight:
- No effects.
- Gross pathology:
- No abnormalities.
- Other findings:
- No effects.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a good quality OECD 423 study conducted to GLP the LD50 was greater than the limit dose of 2000 mg/kg bw/day in rats, as no animals died at this dose. There were no signs of systemic toxicity.
- Executive summary:
The test substance was administered orally by gavage to six CD rats (3/sex) at 2000 mg/kg bw. Animals were then observed daily and weekly determinations of body weight were conducted. Macroscopic examination was performed after terminal sacrifice on day 15. None of the six CD rats died, or showed clinical signs of systemic toxicity. All animals gained body weight within the study period, and no abnormalities were found at macroscopic postmortem examination of the animals. The oral LD50 value for the test substance in CD rats was established to exceed 2000 mg/kg bw.
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