Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-050-9 | CAS number: 10025-99-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reasonable-quality study (on read-across surrogate), not performed to OECD guideline, but it appears to have been well-conducted, matches the guideline in some important respects, and has been adequately reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact hypersensitivity to disodium hexachloroplatinate in mice
- Author:
- Schuppe H-C et al.
- Year:
- 1 997
- Bibliographic source:
- Toxicology Letters, 93 (2,3), 125-133
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- No mention of guideline in publication, but a similar methodology was employed
- Deviations:
- yes
- Remarks:
- Numerous - see "Any other information on materials and methods incl. tables", below
- Principles of method if other than guideline:
- Local lymph node (auricular lymph node; ALN) assay to detect primary immune response.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Disodium hexachloroplatinate hexahydrate
- IUPAC Name:
- Disodium hexachloroplatinate hexahydrate
- Reference substance name:
- Na2[PtCl6].6H2O
- IUPAC Name:
- Na2[PtCl6].6H2O
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Disodium hexachloroplatinate
- Molecular formula (if other than submission substance): Na2[PtCl6].6H2O
- Molecular weight (if other than submission substance): 561.9 g/mol
- Smiles notation (if other than submission substance): [Pt+4]([Cl-])([Cl-])([Cl-])([Cl-])([Cl-])[Cl-].[Na+].[Na+] (dehydrated form)
- InChl (if other than submission substance): 1S/6ClH.2Na.Pt/h6*1H;;;/q;;;;;;2*+1;+4/p-6 (dehydrated form)
- Structural formula attached as image file (if other than submission substance): see Fig. (dehydrated form)
- Substance type: Technical product
- Physical state: No data
- Analytical purity: No data
- Lot/batch No.: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
- Other: supplied by Degussa AG (Hanau, Germany)
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: University of Dusseldorf
- Age at study initiation: 6-8 weeks
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): standard diet (not further specified) ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
Study design: in vivo (LLNA)
- Vehicle:
- other: acetone
- Concentration:
- 5%.
[Results for "lower concentrations" of the test compound were briefly cited in the publication, but no further details were given.] - No. of animals per dose:
- 5
- Details on study design:
- Topical treatment (25 ul) to the dorsum of both ears on 4 consecutive days. Lymph node cells analysed around 48-hours after the last exposure.
End-point: ALN index (cell count from treated group divided by cell count from vehicle control); global ALN cell count (the former is a more sensitive parameter, presumably for measuring immume/sensitisation response.
Controls were treated with vehicle alone [no further details given].
Experiment repeated in triplicate. - Positive control substance(s):
- other: oxazolone, 1% in acetone, single application around 48 hours before ALN cell analysis
- Statistics:
- Results were analyzed for significance emplpying the U-test of Mann-Whitney.
Results and discussion
- Positive control results:
- The positive control caused a 16.5-fold increase in number of proliferating cells compared to the control.
In vivo (LLNA)
Results
- Key result
- Parameter:
- other: ALN cell yield
- Remarks:
- x 1,000,000 cells
- Value:
- 16.9
- Variability:
- Standard deviation +/- 3.7
- Test group / Remarks:
- Mean
- Remarks on result:
- other: 4-Fold increase in global ALN cell yield per animal compared to control (4.3 E6 cells).
- Remarks:
- p<0.01
Any other information on results incl. tables
Compared to controls, the test substance caused a 23-fold increase in number of auricular lymph node (ALN) proliferating cells (ALN index = 22.8), and there was a 4-fold increase in global ALN cell yield per animal (mean global ALN cell yield +/- SD, 16.9 +/- 3.7 vs 4.3 +/- 1.5 (x 1,000,000 cells), p<0.01). The response was said to be comparable to that obtained following a single dose of the potent skin sensitiser oxazolone.
At lower concentrations of test compound [not specified and no further details given], no such increase observed (ALN index <2); the vehicle elicited an ALN index of <1.5 (i.e. reported as no reactivity).
The proliferative response detected in the ALN following skin exposure to sodium hexachloroplatinate was said to provide suggestive evidence for the predominant activation of CD4+ T lymphocytes.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- In a study broadly comparable to the local lymph node assay in mice, disodium hexachloroplatinate induced a proliferation of auricular lymph node (ALN) cells consistent with a potential to cause skin sensitisation.
- Executive summary:
In a study broadly comparable to the local lymph node assay (LLNA), groups of 5 mice were subjected to local applications, on both ears, of 5% disodium hexachloroplatinate on each of 4 consecutive days. Around 48 hours after the last exposure, the auricular lymph nodes cells were analysed.
The test substance caused a 23-fold increase in number of ALN (auricular lymph node) proliferating cells, and a 4 -fold increase in global ALN cell yield per animal compared to vehicle controls. This response was comparable to that seen in the positive control, indicating that disodium hexachlorplatinate has skin sensitisation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.