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EC number: 240-973-0 | CAS number: 16919-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The acute oral LD50 of ammonium hexachloroplatinate is approximately 200 mg/kg bw in rats. Four of five females, but none of five males, died after a single oral dose at this level, suggesting that the LD50 in females maybe somewhat lower than this (Middleton, 1978a).
No relevant acute dermal or inhalation toxicity data were identified.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not carried out in accordance with current guidelines or GLP, but appears scientifically acceptable and well reported.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single acute oral administration of ammonium hexachloroplatinate was given to rats (first main study) at 500 mg/kg bw (the highest dose causing no deaths in a range-finding study). As a high mortality rate was recorded at this level, a second main study was carried out at 200 mg/kg bw.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Olac, Shaw Farm, Blackthorn, Bicester, Oxon
- Age at study initiation: “Young adult”
- Weight at study initiation: 175-320 g
- Fasting period before study: Overnight fast
- Housing: 5 rats (of one sex) in polypropylene cages
- Diet (e.g. ad libitum): ad libitum rodent diet 41B supplied by Pilsbury Ltd, Birmingham
- Water (e.g. ad libitum): ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- Dose administration was by a single peroral injection using a metal cannula. Test material administered in 10 mL vegetable oil.
- Doses:
- In the range-finding study, male and female rats were administered 25, 50, 200, 500 or 2000 mg/kg bw. In the first main study rats were administered 500 mg/kg bw, and in the second main study 200 mg/kg bw
- No. of animals per sex per dose:
- One rat/sex (range-finding study) and ten rats/sex (for the main studies)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Immediately after dosing, 4 hours after dosing, and daily for 14 days.
- Necropsy of survivors performed: yes - Statistics:
- Acute oral median lethal dose (LD50)
- Preliminary study:
- In the range-finding study, both rats died at 2000 mg/kg bw, but no deaths were seen at 500 mg/kg bw and below.
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- 200 mg/kg bw
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- > 200 - < 500 mg/kg bw
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- < 200 mg/kg bw
- Mortality:
- In the range-finding study both rats died at 2 g/kg bw within 24 hrs of dosing; no deaths were seen at any other dose level. In the first main study, 4 male and 4 female rats died at 500 mg/kg bw within 3 days of administration. Therefore a second main study was performed at 200 mg/kg bw. At this level, 4 females died within 24 hrs; the remaining 6 animals (including 5 males) survived the 14-day observation period.
- Clinical signs:
- other: Not reported.
- Gross pathology:
- In the six surviving rats receiving 200 mg/kg bw, pale kidneys were seen in one male and one female rat; no abnormalities were detected in the other 4 males following a macroscopic examination.
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of ammonium hexachloroplatinate is approximately 200 mg/kg bw in rats. Four of five females, but none of five males, died after a single oral dose at this level, suggesting that the LD50 in females maybe somewhat lower than this.
- Executive summary:
- The acute
toxicity of ammonium hexachloroplatinate was investigated in a
well-conducted study Sprague-Dawley rats. Initially, rats (1/sex/group)received
the test material via oral gavage at doses of 25,
50, 200, 500 or 2000 mg/kg bw. Both rats died at the top dose within 24
hours; no deaths were seen at the lower doses. Subsequently, 5 rats/sex
received the test material at a dose of 500 mg/kg bw (the highest dose
causing no deaths in the range-finding study) by stomach tube. As 4 rats
of each sex died within 3 days of administration of the test material at
this dose, a second main study (again involving 5 rats/sex) was performed
at 200 mg/kg bw. At this level, 4 females died within 24 hours, whilst the
remaining animals survived the 14-day observation period.
Of the surviving animals at 200 mg/kg bw, pale kidneys were observed in one male and one female; no gross abnormalities were detected in the other 4 animals. The study authors conclude that the acute oral LD50 of ammonium hexachloroplatinate in the rat is "likely to be in the region of 200 mg/kg bw", and classed the test substance according to Hodge and Sterner (1943) as "moderately toxic". Four of five females, but none of five males, died after a single oral dose of 200 mg/kg bw, suggesting that the LD50 in females may be somewhat below 200 mg/kg bw and in males is greater than 200 mg/kg bw (but less than 500 mg/kg bw). The possible sensitivity of females to ammonium hexachloroplatinate in this test system was not discussed by the study authors.
Based on the results of this study, the test material should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
The acute toxicity of ammonium hexachloroplatinate was investigated in a well-conducted study Sprague-Dawley rats. Initially, rats (1/sex/group) received the test material via oral gavage at doses of 25, 50, 200, 500 or 2000 mg/kg bw. Both rats died at the top dose within 24 hours; no deaths were seen at the lower doses. Subsequently, 5 rats/sex received the test material at a dose of 500 mg/kg bw (the highest dosecausing no deaths in the range-finding study) by stomach tube. As 4 rats of each sex died within 3 days of administration of the test material at this dose, a second main study (again involving 5 rats/sex) was performed at 200 mg/kg bw. At this level, 4 females died within 24 hours, whilst the remaining animals survived the 14-day observation period. Of the surviving animals at 200 mg/kg bw, pale kidneys were observed in one male and one female; no gross abnormalities were detected in the other 4 animals. The study authors conclude that the acute oral LD50 of ammonium hexachloroplatinate in the rat is "likely to be in the region of 200 mg/kg bw", and classed the test substance according to Hodge and Sterner (1943) as "moderately toxic". Four of five females, but none of five males, died after a single oral dose of 200 mg/kg bw, suggesting that the LD50 in females may be somewhat below 200 mg/kg bw and in males is greater than 200 mg/kg bw (but less than 500 mg/kg bw). The possible sensitivity of females to ammonium hexachloroplatinate in this test system was not discussed by the study authors (Middleton, 1978a). Based on the results of this study, the test material should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
No acute inhalation toxicity data were identified. However, as the compound is classified for respiratory sensitisation (category 1A), the corresponding safety/protective measures will ensure that the potential for inhalation exposure is strictly controlled. Hence, exposure at levels sufficient to invoke considerations of acute inhalation toxicity is not anticipated.
Similarly, no acute dermal toxicity data were identified. However, as the compound is classified for skin sensitisation (category 1B), the corresponding safety/protective measures will ensure that the potential for skin exposure is minimised. Moreover, skin contact during production and/or use is expected to be negligible.
Justification for classification or non-classification
Based on the results of the available and reliable acute oral rat study, diammonium hexachloroplatinate should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
No evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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