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Diss Factsheets
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EC number: 944-962-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Based on the available data, the registered substance is considered to be toxic if skin contact and may be harmful by oral route.
No data is available by inhalation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Range-finding toxicity test according to the method described by Smyth HF Jr. et al. (1962).
Smyth HF Jr. et al. (1962). Range-finding toxicity data: List VI. Amer. Ind. Hyg. Ass. J. 23: 95-107 - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- The dosages were arranged in a logarithmic series differing by a factor of two.
- No. of animals per sex per dose:
- 6 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Test conditions and method according to Smyth et al. (1962):
Single oral dose toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, or in rare instances of female rats, four to five weeks of age and 90 to 120 grams. The dosages were arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical was administered undiluted. When a lesser concentration was necessary, solution in water or corn oil or suspension in semi-solid agar were the preferred expedients. Occasionally, a 1 % solution of Tergitol penetrant 7 (essentially an aqueous solution of 25 % sodium 3,9-diethyl-6-tridecanol sulfate) has been used as a dispersing agent. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947). - Statistics:
- The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947).
Thompson WR (1947). Use of Moving Averages and Interpolation to Estimate Median Effective Dose. Bacteriol. Rev. 11: 115 - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.45 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- > 2.57 - < 4.87
- Remarks on result:
- other: with a density of 1.037, the LD50 is 3577 mg/kg bw
- Mortality:
- yes, no details
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on the results, the oral LD50 of 1,3-butylene glycol diacrylate is 3577 mg/kg (corresponding to 3.45 ml/kg bw) in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 577 mg/kg bw
- Quality of whole database:
- The study of carpenter is considered to be reliable.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Range-finding toxicity test according to the method described by Smyth HF Jr. et al. (1962).
Smyth HF Jr. et al. (1962). Range-finding toxicity data: List VI. Amer. Ind. Hyg. Ass. J. 23: 95-107 - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: impervious plastic film
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 h
- Duration of exposure:
- 24 h
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Test conditions and method according to Smyth et al. (1962):
Penetration of rabbit skin was estimated by a technique closely akin to the one-day cuff method of Draize et al. (1944) using groups of four male albino New Zealand rabbits weighing 2.5 to 3.5 kg. The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervious plastic film. Dosages greater than 20 mL/kg bw could not be retained in contact with the skin. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14-day observation period. The LD50 was calculated by the method of Thompson (1947). - Statistics:
- The LD50 was calculated by the method of Thompson (1947).
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.45 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- > 0.21 - < 0.95
- Remarks on result:
- other: with the density of 1.037, the dermal LD50 is 466 mg/kg bw
- Mortality:
- yes, no details
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on the data, the dermal LD50 of 1,3-butylene glycol diacrylate is 466 mg/kg bw (corresponding to 0.45 ml/kg bw) in rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 466 mg/kg bw
- Quality of whole database:
- The study of carpenter is considered to be reliable.
Additional information
The Carpenter's publication (1974) summarizes the results of the acute toxicity studies performed by oral and dermal routes on butane-1.3-diyl diacrylate.
Based on the results, the oral LD50 of 1,3-butylene glycol diacrylate is 3577 mg/kg (corresponding to 3.45 ml/kg bw) in rats, and the dermal LD50 of 1,3-butylene glycol diacrylate is 466 mg/kg bw (corresponding to 0.45 ml/kg bw) in rabbits.
Justification for classification or non-classification
Oral acute toxicity
Based on the available data (oral LD50 of 3577 mg/kg), absence of mandatory classification of Butane-1,3-diyl diacrylate for this endpoint and the composition of the registered substance (containing 65 -100 % of Butane-1,3-diyl diacrylate), no classification of the registered substance is required for oral acute toxicity.
Dermal acute toxicity
Butane-1,3-diyl diacrylate (CAS number 19485 -03 -1) has a mandatory classification according to the Regulation EC 1272/2008 (Annex VI, index number: 607-118-00-7): Acute tox. 4* by dermal route (H312).
The available data showed a dermal LD50 of 466 mg/kg, corresponding to the category 3 of CLP.
Based on the available data (dermal LD50 of 466 mg/kg), the mandatory classification of Butane-1,3-diyl diacrylate (Acute tox. 4* by dermal route) and the composition of the registered substance (containing 65 -100% of Butane-1,3-diyl diacrylate), the following classification is applied : Acute tox.3 for dermal route (H311).
Inhalation acute toxicity
Based on the absence of data and the absence of mandatory classification of Butane-1,3-diyl diacrylate for this endpoint, no classification of the registered substance is required for inhalation acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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