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EC number: 238-523-3 | CAS number: 14516-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
In an oral gavage prenatal developmental toxicity study in rabbits with TBBC, anorexia and spontaneous abortions were observed in dams treated at 20 mg/kg bw/day; the NOAEL for maternal toxicity is 2 mg/kg bw/day (Proctor and Gamble, 1976). Significant decreases in mean pup weight and litter size occurred at 2 mg/kg-day; the NOAEL for developmental toxicity is 0.2 mg/kg bw/day. The Klimisch score of this study was not assignable due to the lack of the identity and purity of the substance and number of animals per dose.
A two-month oral study with TBBC that assessed male reproductive toxicity, decreased sperm production and histopathological changes in seminiferous tubules of rats and mice at 41-57 and 82-99 mg/kg bw/day, respectively (lowest doses tested) were observed (Takahashi and Oishi, 2006). The Klimisch score of this study was not assignable due to the lack of a standard protocol and number of animals per dose.
In the 90 day and 2 year feed studies in rats (F344/n) and mice (B6C3F1) with TBBC, no effects were observed in any reproductive organs. Therefore the toxicity to reproduction (screening) test for UV-1084 is waived.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In an oral gavage prenatal developmental toxicity study in rabbits with TBBC, anorexia and spontaneous abortions were observed in dams treated at 20 mg/kg bw/day; the NOAEL for maternal toxicity is 2 mg/kg bw/day (Proctor and Gamble, 1976). Significant decreases in mean pup weight and litter size occurred at 2 mg/kg-day; the NOAEL for developmental toxicity is 0.2 mg/kg bw/day. The Klimisch score of this study was not assignable due to the lack of the identity and purity of the substance and number of animals per dose.
A two-month oral study with TBBC that assessed male reproductive toxicity, decreased sperm production and histopathological changes in seminiferous tubules of rats and mice at 41-57 and 82-99 mg/kg bw/day, respectively (lowest doses tested) were observed (Takahashi and Oishi, 2006). The Klimisch score of this study was not assignable due to the lack of a standard protocol and number of animals per dose.
In the 90 day and 2 year feed studies in rats (F344/n) and mice (B6C3F1) with TBBC, no effects were observed in any reproductive organs. Therefore the toxicity to reproduction (screening) test for UV-1084 is waived.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available information in the dossier, the substance UV1084 (CAS No. 14516-71-3) does not need to be classified for reproductive toxicity when the criteria outlined in Annex I of 1227/2008/EC are applied based on the weight of evidence from TBBC(CAS No. 96-69-5).
Additional information
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