Registration Dossier
Registration Dossier
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EC number: 283-815-6 | CAS number: 84731-55-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
There are no data available for the acute toxicity of lithium isooctadecanoateso data have been read across from lithium 12-hydroxystearate. Lithium isooctadecanoate and lithium 12-hydroxystearate are both lithium salts of C18 monocarboxylic acids, with lithium isooctadecanoate having a methyl branch on the carbon chain and lithium 12-hydroxystearate having a hydroxyl group on the carbon chain. See IUCLID section 13 for read across justification.
The acute toxicity of lithium 12-hydroxystearate to fish showed no effects at a water accommodated fraction loading rate of 100 mg/L, so the 96-hour LL50 is determined to be > 100 mg/L WAF for lithium 12-hydroxystearate and this value is read across to lithium isooctadecanoate.
Key value for chemical safety assessment
Additional information
The acute toxicity to fish of lithium 12-hydroxystearate has been read across to lithium isooctadecanoate. The toxicity to fish was determined in a GLP-compliant, limit test (Harlan 2013), following OECD guideline 203. As no effects were observed in the Daphnia and algae toxicity tests or the preliminary range finding test for acute toxicity to fish, the definitive toxicity to fish test was conducted as a limit test at 100 mg/L, alongside a blank control. Seven fish were exposed to water accommodated fractions of lithium 12-hydroxystearate for 96 hours in standard ecotoxicity media adjusted to a hardness of approximately 150 mg/L CaCO3. Observations of mortalities or abnormalities of behaviour or appearance of the fish were made at 3, 6, 24, 48, 72 and 96 hours and the test solutions analysed for lithium content and total organic carbon at test initiation and termination. The acute toxicity to fish study on lithium 12-hydroxystearate did not show any effects at 100 mg/L WAF. This result has been read across to lithium isooctadecanoate.
The result is supported by the data reviewed in the API (2008) and HPV Characterisation (2003, 2009) documents, reporting the acute toxicity to fish of lithium 12-hydroxystearate to give a 96-hour LC50 of >2000 mg/L. Only a summary of the study from a secondary source is available and, although the original proprietary study (Stonybrook 1992b) has not been reviewed, the API gave a Klimisch score of 2, “test not conducted under full GLP regulations”.
Lithium 12-hydroxystearate has a 96-hour LL50 of >100 mg/L WAF to fish. As the substance is not acutely toxic to fish, it can be justifiably expected that lithium isooctadecanoate will not be acutely toxic to fish either.
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