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Diss Factsheets
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EC number: 202-912-6 | CAS number: 101-07-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1953
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 953
- Report date:
- 1953
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-[bis(2-ethylhexyl)amino]ethanol
- EC Number:
- 202-912-6
- EC Name:
- 2-[bis(2-ethylhexyl)amino]ethanol
- Cas Number:
- 101-07-5
- Molecular formula:
- C18H39NO
- IUPAC Name:
- 2-[bis(2-ethylhexyl)amino]ethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- A sample of di (2-ethylhexyl) ethanolamine (S-5223) was received from S. Charleston on 11-12-52 for toxicological assay.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male albino New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg in weight were utilized in the study. The rabbits were procured locally and maintained on Rockland rabbit ration.
Administration / exposure
- Type of coverage:
- other: "Vinylite" sheeting was used to retain the dose in contact with the clipped skin.
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The rabbits were immobilzed during the 24 hour skin contact period. Thereafter, the "vinylite" sheeting used to retain the dose in contact with the clipped skin of the trunk was removed and the animals were caged for the remainder of the 14-day observation period.
- Duration of exposure:
- 24 hours
- Doses:
- Dosage (ml/kg): 0.63, 1.26, 2.52, 5.0
- No. of animals per sex per dose:
- Four animals per dose with the exception of the 0.63 ml/kg group which only had one animal.
- Control animals:
- no
- Details on study design:
- Animals were weighed prior to dosing and at the end of the 14-day observation period.
- Statistics:
- Thompson's method of calculating the LD50 was used. For calculation of the LD50 by Thompson's method the survival of 3 rabbits was assumed for 0.63 ml/kg.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- Three of the four animals dosed in the 2.52 and the 5.0 ml/kg dose groups died. All other animals survived.
- Clinical signs:
- other: Erythema and desquamation of the skin was caused by the application.
- Gross pathology:
- Lung damage was severe among those dying and livers were mottled.
- Other findings:
- This compound penetrates skin readily as may be seen by comparing these results with methyl diethanolamine which had a rat oral LD50 of 1.8 gm/kg and rabbit skin penetration LD50 of 11.9 ml/kg.
Applicant's summary and conclusion
- Conclusions:
- The undiluted compound had an LD50 for rabbits of 2.5 (1.3 to 4.8) ml/kg.
- Executive summary:
In a skin penetration study conducted on male albino New Zealand rabbits, the undiluted test material was applied using "vinylite" sheeting to the clipped skin of the trunk of the animals for a 24 hour exposure period at either 0.63, 1.26, 2.52 or 5.0 ml/kg. Animals were weighed prior to dosing and at the end of the 14-day observation period. Thompson's method of calculating the LD50 was used. Three of the four animals dosed in the 2.52 and the 5.0 ml/kg dose groups died. All other animals survived. Erythema and desquamation of the skin was caused by the application. All but one animal lost weight during the course of the study. One animal in the 5.0 ml/kg dose group gained weight. Lung damage was severe among those dying and livers were mottled. The undiluted compound had an LD50 for rabbits of 2.5 (1.3 to 4.8) ml/kg.
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