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Diss Factsheets
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EC number: 216-407-3 | CAS number: 1576-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- No testing data on skin sensitisation is available for Toluene-4-sulphonohydrazid (TSH).
Predictions performed on dataset from different in silico prediction models (Danish QSAR database, QSAR Vega, ToxTree; OECD QSAR Toolbox) no valid conclusion can be derived for skin sentisation of TSH.
Data source
Reference
- Reference Type:
- other: Q(SAR) prediction report
- Title:
- (Q)SAR predicted profile for toluene-4-sulphonohydrazide
- Year:
- 2 022
- Bibliographic source:
- Danish Q(SAR) database
- Report date:
- 2022
Materials and methods
- Principles of method if other than guideline:
- in silico prediction models
- Danish QSAR database
- QSAR Vega (v 1.2.0)
- ToxTree (v3.1.0-1851-1525442531402)
- OECD QSAR Toolbox
Test material
- Reference substance name:
- Toluene-4-sulphonohydrazide
- EC Number:
- 216-407-3
- EC Name:
- Toluene-4-sulphonohydrazide
- Cas Number:
- 1576-35-8
- Molecular formula:
- C7H10N2O2S
- IUPAC Name:
- toluene-4-sulphonohydrazide
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Group:
- other:
- Run / experiment:
- other: QSAR prediction
- Parameter:
- other: QSAR prediction
- Cell viability:
- QSAR model
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
In vivo (non-LLNA)
Results
- Key result
- Reading:
- other: QSAR prediction
- Group:
- other: QSAR prediction
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
In vivo (LLNA)
Results
- Key result
- Parameter:
- other: QSAR prediction
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
Any other information on results incl. tables
No testing data on skin sensitisation available for TSH.
Using different QSAR models, no valid prediction could be made. Only one model predicted TSH to have skin sensitising properties, but this prediction was with low reliability.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisation.
Therefore, as a precautious approach TSH is classified accordingly as a skin sensitiser (Skin Sens. 1 (H317).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitization.
- Executive summary:
No testing data on skin sensitisation is available for Toluene-4-sulphonohydrazid (TSH).
Form QSAR prediction on skin sensitisation using the Danish QSAR database (see attached prediction report), no valid prediction could be derived using a battery approach (3 seperate predictions from CASE Ultra, Leadscope and SciQSAR). The predictions for skin sensitisation and irritation in animal models (Guinea pig and rabbit) was outside applicability domain. Further, in the same prediction report from the Danish QSAR database, no alert for protein binding and potency estimation was found using different models (OASIS, OECD QSAR Toolbox, DRPA).
Prediction on skin sensitisation of TSH using the QSAR Vega tool (CAESAR model) revealed a positive prediction but with low reliability score (see attached prediction report).
Also, using the Toxtree programme, no alrets was identified for skin sensitisastion.
Based on the overall dataset from different in silico prediction models (Danish QSAR database, QSAR Vega, ToxTree; OECD QSAR Toolbox) no valid conclusion can be derived for skin sentisation of TSH.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisatin.
Thus, a precautinary approach would be to consider TSH as a skin sensitiser and classify accordingly (Skin Sens. 1 (H317).
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