(R)-3-(1-methyl-2-pyrrolidinylmethyl)-5-[2-(phenylsulphonyl)ethyl]-1H-indole

Guidance on Safe Use

First-aid measures

Description of First Aid Measures

Eye Contact: Immediately flush eyes with water for at least 15 minutes. Get medical attention.

Skin Contact: Remove clothing and wash affected skin with soap and water. This material may not be

completely removed by conventional laundering. Consult professional laundry service. Do not

home launder. If irritation occurs or persists, get medical attention.

Ingestion: Get medical attention immediately. Do not induce vomiting unless directed by medical

personnel. Never give anything by mouth to an unconscious person

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. Get medical attention

immediately.

Fire-fighting measures

Extinguishing Media: Use water spray, foam, dry powder, or carbon dioxide.

Special Hazards Arising from the Substance or Mixture

Hazardous Combustion

Products:

Emits toxic fumes of carbon monoxide, carbon dioxide, oxides of nitrogen, sulfur oxides, and

other sulfur-containing compounds

Fire / Explosion Hazards: Very high sensitivity of a dust cloud to ignition, based on minimum ignition energy.

Advice for Fire-Fighters

Wear approved positive pressure, self-contained breathing apparatus and full protective turn out gear.

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures

Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure.

Environmental Precautions

Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.

Methods and Material for Containment and Cleaning Up

Measures for Cleaning /

Collecting:

Contain the source of the spill if it is safe to do so. Collect spilled material by a method that

controls dust generation. Avoid use of a filtered vacuum to clean spills of dry solids, due to the

potential for electrostatic discharge and very high sensitivity to ignition. Clean spill area

thoroughly.

Additional Consideration for

Large Spills:

Non-essential personnel should be evacuated from affected area. Report emergency

situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

7. HANDLING AND STORAGE

Precautions for Safe Handling

Ground and bond all bulk transfer equipment. Avoid open handling. Minimize dust generation. Use local exhaust ventilation or

perform work under fume hood/fume cupboard. Avoid inhalation and contact with skin, eye, and clothing. When handling, use

appropriate personal protective equipment (see Section 8). Wash hands and any exposed skin after removal of PPE. Releases

to the environment should be avoided. Review and implement appropriate technical and procedural waste water and waste

disposal measures to prevent occupational exposure or environmental releases. Potential points of process emissions of this

material to the atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent controls. Refer

to Section 12 - Ecological Information, for information on potential effects on the environment.

Conditions for Safe Storage, Including any Incompatibilities

Storage Conditions: Store in a cool, dry, well-ventilated area. Keep container tightly closed when not in use.

Storage Temperature: Store at ambient temperature

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

not listed

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

not listed

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

not listed

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Analytical Method: Analytical method available. Contact Pfizer Inc for further information.

Exposure Controls Engineering Controls: Engineering controls should be used as the primary means to control exposures. Use process containment, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits.

Personal Protective Equipment: Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE).

Hands: Wear impervious gloves as minimum protection.

Eyes: Wear safety goggles as minimum protection.

Skin: Wear impervious protective clothing when handling this compound.

Respiratory protection: If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL.

Stability and reactivity

Reactivity: No data available

Chemical Stability: Stable at ambient temperatures

Possibility of Hazardous Reactions

Oxidizing Properties: No data available

Conditions to Avoid: Eliminate possible ignition sources (e.g., heat, sparks, flame, impact, friction, electrostatic

discharge).

Incompatible Materials: As a precautionary measure, keep away from strong oxidizers

Hazardous Decomposition

Products:

None expected under normal conditions.

Disposal considerations

SIDERATIONS

Waste Treatment Methods: Dispose of waste in accordance with all applicable laws and regulations. Member State

specific and Community specific provisions must be considered. Considering the relevant

known environmental and human health hazards of the material, review and implement

appropriate technical and procedural waste water and waste disposal measures to prevent

occupational exposure and environmental release. It is recommended that waste minimization

be practiced. The best available technology should be utilized to prevent environmental

releases. This may include destructive techniques for waste and wastewater.