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EC number: 919-489-5 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-11-23 to 2015-11-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.27 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: equilibrated at least overnight
- Details on results:
- The temperatures were kept constant within ± 0.5 °C.
No Tyndall-effects were observed for any of the equilibrium samples confirming the absence of colloidal dispersed material.
The pH-value was determined with indicator sticks to be in the range of 7 for each sample. - Conclusions:
- The water solubility of the test substance was determined to be 0.27 mg/L at 20 °C.
- Executive summary:
The water solubility was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item in water was determined employing the column elution method at 20 ± 0.5 °C with equilibration overnight. The analytical method (GC-MS) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test substance was determined to be 0.27 mg/L at 20 °C.
Reference
Solubility Results for test item at 20 °C
(dilution factor of 6.25 and exact weight of the external standards taken into account)
Sampling of equilibrium |
Test item concentration [mg/L] |
|
|
0.4 mL/min |
0.2 mL/min |
||
1 |
0.271 |
0.277 |
|
2 |
0.285 |
0.238 |
|
3 |
0.228 |
0.295 |
|
4 |
0.234 |
0.304 |
|
5 |
0.261 |
0.306 |
Overall |
Mean |
0.253 |
0.284 |
0.270 |
Deviation [%] |
25 |
28 |
11 |
SD ± |
0.024 |
0.057 |
|
Description of key information
The water solubility of the test substance was determined to be 0.27 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.27 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item in water was determined employing the column elution method at 20 ± 0.5 °C with equilibration overnight. The analytical method (GC-MS) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test substance was determined to be 0.27 mg/L at 20 °C.
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