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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data provided.
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Experimental studies with limited information provided.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1957
Report date:
1957
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Ear drops containing the test substance were tested for irritation properties on skin, eye and ear in rabbits.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichlorobenzyl alcohol
EC Number:
217-210-5
EC Name:
2,4-dichlorobenzyl alcohol
Cas Number:
1777-82-8
Molecular formula:
C7H6Cl2O
IUPAC Name:
(2,4-dichlorophenyl)methanol

Results and discussion

Any other information on results incl. tables

Eye:

Lacrymation was observed within 30 min but was not detected after 2 h or later. The same effect was observed in the vehicle treated eye. During further observations the eyes appeared normal.

Skin:

No signs of irritation were observed after one application and after repeated application.

Ear:

There was no demonstrable damage to the outer ear of the guinea pigs after application. One ear treated with the control showed inflammatory responses. This effect was not detected in the other control ear and also not ears treated with polyethylene glycol alone in other experimental studies. The observed inflammation subsided by the sixth day following completion of treatment.

Applicant's summary and conclusion