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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: Determination of the acute oral LD50 value
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetylcysteine
EC Number:
210-498-3
EC Name:
Acetylcysteine
Cas Number:
616-91-1
Molecular formula:
C5H9NO3S
IUPAC Name:
N-acetylcysteine

Test animals

Species:
mouse

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
6 400 mg/kg bw
Based on:
test mat.
95% CL:
> 5 565 - < 7 360
Clinical signs:
other: Mice showed a general lethargy, lack of mobility and depressed/narrowed breathing.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In the review an LD50 for acute oral toxicity of 6400 mg/kg bw in mice was reported.
Executive summary:

In the review an LD50 for acute oral toxicity of 6400 mg/kg bw in mice was reported. Furthermore, mice showed a general lethargy, lack of mobility and depressed/narrowed breathing.