Registration Dossier
Registration Dossier
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EC number: 203-662-0 | CAS number: 109-29-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Ten rats (sex unknown) were orally exposed to oxacycloheptadecan-2-one at 5,000 mg/kg bw. Rats were observed for 14 days, clinical signs were noted.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Oxacycloheptadecan-2-one
- EC Number:
- 203-662-0
- EC Name:
- Oxacycloheptadecan-2-one
- Cas Number:
- 109-29-5
- Molecular formula:
- C16H30O2
- IUPAC Name:
- oxacycloheptadecan-2-one
- Test material form:
- not specified
- Details on test material:
- Sample marking: 74-206 HEXADECANOLIDE
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details given.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- Rats were found to be slightly lethargic (no further details given).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Ten rats (sex unknown) were orally exposed to 5,000 mg oxacycloheptadecan-2-one/kg bw. During the observaton period of 14 days, no mortality occurred. Rats were found to be slightly lethargic. Based on this data it can be concluded that the oral LD50 of oxacycloheptadecan-2-one exceeds 5000 mg/kg bw.
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