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EC number: 240-941-6 | CAS number: 16898-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb-July, 992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-(1,3-Propanediyl)dipiperidine
- Cas Number:
- 16898-52-5
- Molecular formula:
- C13H26N2
- IUPAC Name:
- 1,1'-(1,3-Propanediyl)dipiperidine
- Test material form:
- solid
- Details on test material:
- Purity 100%, Brownish White Flaky Solid, Lot # 11202AB
Constituent 1
- Specific details on test material used for the study:
- Brownish white flaked solid, Lot # 11202AB
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Ten healthy young adult New Zealand White rabbits, five of each sex, were used in the study.
Animals were purchased from a registered commercial breeding laboratory (Eastern Rabbit Breeding laboratory, Taunton, MA)
Animals were in the weight range between 2.0 and 3.0 kilograms at the start of the study
Animals were 10-12 weeks old at the start of the study. They were quarantined for 5 days prior to the study.
Animals were all housed individually using suspended stainless steel cages marked with the corresponding animal number.
Hardwood Sani-chips were used as non-contact bedding under the cages.
Animal rooms were maintained at 68±F at 30-70% Humidity
A minimum of 10-13 complete air exchanges per house occured
12 hour light/dark cycles using full spectrum fluorescent lights were used.
Animals were supplied with a commercial rabbit ration (Agway Prolab, Waverly, NY) and municipal tap water ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Animals were weighed prior to testing and their fur clipped 24 h prior to adminstration of test material. The test substance was introduced under gauze patches two single layers thick and applied directly to the skin of the body surface (approximately 10%) of each of the ten animals. Animals were immobilized and the patches were secured in place by wrapping the entire trunk of the animal with an impervious bandaging.
- Duration of exposure:
- 24 hours
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
- Details on study design:
- After the exposure period, the wrapping was removed from the animals and the site rinsed gentily with USP water to remove remaining test material. Any skin lesions found were graded 30-60 minutes after bandage removal. Animals were observed for erythema and edema for a 24 h observation period. The animals were observed daily for 14 days. Any animal found dead was necropsied within 12 hours. All animals underwent a gross necropsy. Surviving animals were euthanised with an injectable barbiturate, Euthanasia-5 (Veterinary Laboratories Inc, Lenexa , KS, USA).
- Statistics:
- none
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- given as > 2 g/kg
- Mortality:
- No animals died during the 14 day observation period
- Clinical signs:
- other: There were no overt signs of toxicity exclusive of skin irritation noted in any test animal during the observation period. There was no evidence the animals experienced pain or suffering
- Gross pathology:
- Necrosis was observed in the skin in all animals. Gross necropsy showed that necrosis penetrated through the skin into the underlying muscle. It also showed atrophy of the spleen and discoloration of the liver and kidneys.
Any other information on results incl. tables
LD50 > 2 g/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance is considered nontoxic in rabbits at a dose of 2000 mg/kg bw for 24 h, occlusive exposure, based upon the absense of mortality in a 14 day limit dose acute dermal toxicity study. Necrosis of the skin was observed in all animals at necropsy but no other clinical signs were reported.
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