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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation
Remarks:
no data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication supporting the waiving arguments.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloroacetic acid
EC Number:
201-207-0
EC Name:
Dichloroacetic acid
Cas Number:
79-43-6
Molecular formula:
C2H2Cl2O2
IUPAC Name:
2,2-dichloroacetic acid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Remarks on result:
other: strongly irritating
Irritant / corrosive response data:
strongly irritating

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information
Conclusions:
The grade of eye hazard given is explained by Carpenter and Smyth. Eye injury in rabbits from fluid was 10/10.
Executive summary:

Eye iinjury in rabbits from fluid was 10/10, indicating highly corrosive activity. Therefore most conservatie classification as irriversible effects on the eyes is proposed and further testing is avoided.