Furan, 2-(ethoxymethyl)tetrahydro-

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1997 (SI 1997/654)). These Regulations are in accordance with GLP standards published as OECD Principles on Good Laboratory Practice (revised 1997, ENV/MC/CHEM(98)17); and are in accordance with, and implement, the requirements of Directives 87/18/EEC and 88/320/EEC.

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

GLP compliance:

yes (incl. QA statement)

Test performance:

Less than 10% hydrolysis after 5 days at 50'C, equivalent to a half- life greater than 1 year at 25 'C.

Transformation products:

no

pH:

4

Temp.:

50 °C

Hydrolysis rate constant:

< 10 d-1

DT50:

> 1 yr

pH:

7

Temp.:

50 °C

Hydrolysis rate constant:

< 10 d-1

DT50:

> 1 yr

pH:

9

Temp.:

50 °C

Hydrolysis rate constant:

< 10 d-1

DT50:

> 1 yr

Details on results:

The analytical method has been determined to be substance specific and of sufficient accuracy for the test material in this study.

Conclusions:

Please refer to results.

Description of key information

Low rate of hydrolysis; not considered to be a significant degradation process

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

25 °C

Additional information

The half-life at25°Cof Ethyl tetrahydrofurfuryl ether is shown in Table 10.1.

Table 10.1

pH	Estimated half-life at25'C
4	Greater than 1 year
7	Greater than 1 year
9	Greater than 1 year