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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 222-940-2 | CAS number: 3674-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Experimental data on the potential of skin sensitisation are not available for the substance.
As a result of an overall assessment of the QSAR predictions (detailed in Table below) the substance can not be classified for skin sensitisation.
Predicted data are inconclusive for the classification of the substance as skin sensitizer since all the results obtained by qualitative models are not reliable; moreover, not all models identify one structural alert (e.g. Protein binding potency, Protein binding alerts for skin sensitization according to GHS).
|
Name of the software |
Model/module |
Model type |
Result |
Skin sensitization |
QSAR Toolbox |
Proteing binding profilers OASIS |
Structural alerts |
SN2
Profile responsible for interaction with proteins and especially with skin proteins
|
Proteing binding profilers OECD |
Structural alerts |
SN2
1,2-dihaloalkanes undergo an initial attack by glutathione followed by internal cyclisation resulting in the formation of a reactive episulfonium ion
|
||
Proteing binding potency |
Structural alerts |
Not possible to classify according to these rules (GSH)
|
||
Protein binding alerts for skin sensitization by OASIS |
Structural alerts |
SN2 α-Activated haloalkanes. The chemicals are strong sensitizers as a result of Nucleophilic substitution on halogenated Csp3-atom. This profiler is to investigate the presence of alerts within the target molecules responsible for interaction with proteins and especially with skin proteins.
|
||
Protein binding alerts for skin sensitization according to GHS |
Structural alerts |
No alert found |
||
ToxTree |
Skin sensitisation reactivity domains |
Structural alerts |
Alert for SN2 identified |
|
VEGA |
Skin sensitisation CAESAR |
Qualitative
Skin sensitisation model in VEGA: aggregated data from Gebericket al.(2005) (extreme, strong and weak sensitisers coded as positive, NC as negative) |
Prediction non-reliable, the predicted compound is outside the Applicability Domain of the model |
|
Danish (Q)SAR database |
Skin sensitisation (CASE Ultra, Leadscope and SciQSAR) |
Qualitative
Several factors were considered in the activity classification including: the type of assay used, i.e. human or guinea pig maximization test; use of adjuvant; dose used for challenge; and the sensitisation rate. Weak, moderate, strong and extreme sensitizers were included in the model training set as positive and non-sensitizers were included as negative. |
Prediction non-reliable. The predicted compound is outside the Applicability Domain of all models as shown below:
Battery NEG_OUT CASE Ultra POS_OUT Leadscope INC_OUT SciQSAR NEG_IN
Only one it is inside applicability domain. |
|
Abbreviations INC: inconclusive. A definite call within the defined applicability domain could not be made. NEG: negative POS: positive IN: inside applicability domain OUT: outside applicability domain |
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Experimental data on the potential of skin sensitisation are not available for the substance.
As a result of an overall assessment of the QSAR predictions (detailed in Table above) the substance can not be classified for skin sensitisation.
Predicted data are inconclusive for the classification of the substance as skin sensitizer since all the results obtained by qualitative models are not reliable; moreover, not all models identify one structural alert (e.g. Protein binding potency, Protein binding alerts for skin sensitization according to GHS).
Overall, available data are inconclusive for the classification of the substance.
Additional labelling requirements
KLOB-010 contains as impurity the substance methyl acrylate (EC 202-500-6 - CAS 96-33-3) at 0.3 %.
According to the harmonised classification and labelling (CLH) approved by the European Union, this substance is a highly flammable liquid and vapour, is harmful if swallowed, is harmful in contact with skin, causes serious eye irritation, is harmful if inhaled, causes skin irritation, may cause an allergic skin reaction and may cause respiratory irritation. Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic if inhaled and is harmful to aquatic life with long lasting effects.
Beacuse, it is above the concentration limits for elicitation 0.1%, this concentration limit is used for the application of the special labelling requirements of section 2.8 of Annex II to protect already sensitised individuals.
The following statement is required:
- EUH208 - Contains (Methyl acrylate). May produce an allergic reaction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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