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EC number: 229-856-5 | CAS number: 6789-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50: 12300 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not indicated
- Age at study initiation: not indicated
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- No details on housing, diet or environmental conditions were provided.
IN-LIFE DATES: not indicated - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Six male rats were given a single dose. The size of the initial dosage was judged by previous experience with hundreds of other materials. Doses started at 10 g/kg bw and decreased with a factor 10. The test solution was always diluted with water or dispersed in water so that reasonable accuracy in volume measurement was possible. One week later, six more animals were given some other dosage and this procedure was repeated until two dosages differing by a multiple of ten were found, one of which within fourteen days killed some or all animals and the other of which killed some or no animals.
- Doses:
- Not spcecified
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- No further details were provided.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 12 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 11 300 - < 13 500
- Mortality:
- No information on mortality was provided.
- Clinical signs:
- other: No information on observed clinical signs was provided.
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- according to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- The acute oral toxicity test with the substance showed an LD50 of 12300 mg/kg bodyweight.
- Executive summary:
In the oral toxicity study the substance was assessed for acute toxicity. 6 male rats were exposed to the substance by gavage using a fixed dose procedure. This procedure was repeated after 14 days, until two doses were found that provided sufficient information for determining an LD50. The LD50 for the substance was 12300 mg/kg bodyweight.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Oral toxicity:
In the oral toxicity study the substance was assessed for acute toxicity. 6 male rats were exposed to the substance by gavage using a fixed dose procedure. This procedure was repeated after 14 days, until two doses were found that provided sufficient information for determining an LD50. The LD50 for the substance was 12300 mg/kg bodyweight.
Justification for classification or non-classification
Based on the results of the acute oral toxicity study, the substance is not classified as acute harmful according to Regulation (EC) No. 1272/2008 and its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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