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Diss Factsheets
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EC number: 237-280-0 | CAS number: 13718-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
The effects of dietary Se on Sea Urchin (Lytechinus variegatus) growth were studied experimentally.
- Short description of test conditions:
Semipurified formulated feeds containing 0.6, 1.1, or 2.4 mg selenium/kg feed (as sodium selenite) for 12 wk (n = 16 individuals per feed treatment, 15.59 ± 0.18 SE g initial wet weight, 31.29 ± 0.12 SE mm diameter; 32 ± 2 ppt salinity and 22 ± 1 C).
- Parameters analysed / observed:
diameter, body weight - GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium selenite
- EC Number:
- 233-267-9
- EC Name:
- Sodium selenite
- Cas Number:
- 10102-18-8
- Molecular formula:
- H2O3Se.2Na
- IUPAC Name:
- disodium selenite
Constituent 1
- Specific details on test material used for the study:
- Source: Zeigler Bros, Inc., Gardners, Pennsylvania, USA
Results and discussion
Any other information on results incl. tables
Survival was 100% in all treatments over the 12-wk study period.
At week 12, test diameters inL.variegatusfed 1.1 mg selenium/kg feed were significantly larger (P <0.05) than those in sea urchins fed 2.4 mg selenium/kg feed but not those fed 0.6 mg selenium/kg feed. Mean wet and dry weights increased significantly (P <0.05) in sea urchins fed selenium feeds during the 12-wk study. At week 12, sea urchins fed 0.6 and 1.1 mg selenium/kg feed had signifi- cantly higher (P <0.05) wet and dry weights than those fed 2.4 mg selenium/kg feed (P=0.0024, P=0.0007, respectively), resulting in higher SGR (Table 4).
Sea urchins fed 2.4 mg selenium/kg feed had conspicuous signs of pathology. Four sea urchins fed 2.4 mg selenium/kg feed had gas-filled membrane distensions (resembling those found in mammalian enterocolitis), green lanterns instead of white, and/or red coelomic fluid upon dissection at 12 wk.
Applicant's summary and conclusion
- Conclusions:
- High levels of dietary selenium (2.4 mg Se/kg feed) significantly decreased weight gain, test diameter, test wet weight, and dry ovary production compared to sea urchins fed the 0.6 and/or the 1.1 mg selenium/kg feed, suggesting that high levels of dietary selenium negatively affect sea urchin physiology. Observable pathologies in sea urchins fed high levels of dietary selenium included red coelomic fluid and pigmented organs, consistent with an inflammatory response. Additionally, selenium accumulated in the gut, gonad, and test at levels generally proportional to selenium in the feed. A selenium requirement is suggested but not established in this 12-wk study. These data suggest toxicity for high levels of dietary selenium in L. variegatus, resulting in a variety of growth inhibitions and pathologies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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