Registration Dossier
Registration Dossier
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EC number: 209-665-3 | CAS number: 589-92-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1959
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information on a guideline was reported, but assumed to be standard acute method.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylcyclohexanone
- EC Number:
- 209-665-3
- EC Name:
- 4-methylcyclohexanone
- Cas Number:
- 589-92-4
- Molecular formula:
- C7H12O
- IUPAC Name:
- 4-methylcyclohexan-1-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
Not reported.
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
Not reported.
- Test material: undiluted
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Not reported.
ENVIRONMENTAL CONDITIONS
Not reported.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE:
Not reported.
MAXIMUM DOSE VOLUME APPLIED:
Not reported. - Doses:
- 50, 400 and 3200 mg/kg
- No. of animals per sex per dose:
- 3 rats reported (assumed to be total, with one per dose)
- Control animals:
- not specified
- Details on study design:
- Not reported.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 400 - <= 3 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- time to death: 1 hour
- Clinical signs:
- other: Symptoms slight to very weak.
- Gross pathology:
- Not reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The reported LD50 was 400 to 3200 mg/kg for rats.
- Executive summary:
Undiluted test substance was applied orally to rats at doses of 50, 400 and 3200 mg/kg. The resulting LD50 is 400 to 3200 mg/kg.
There were only slight to very weak symptoms observed. Time until death was 1 hour.
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