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EC number: 265-929-8 | CAS number: 65799-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
[3-(2,3-Epoxypropoxy)propyl]dimethoxy(methyl)silane is a liquid at standard temperature and pressure, with a melting point of < -80 °C, and a measured boiling point of 250.9 ± 2.1 °C (OECD 103, A.2. method 2008). It has a measured relative density of 1.02 at 20.6 °C (OECD 109, EC A.3. method 2008) and a predicted vapour pressure of 3.0 Pa at 25 °C.
The substance is not classified for flammability according to Regulation (EC) No. 1272/2008 on the basis of a measured flash point of 118 °C and a measured boiling point of 250.9 ± 2.1°C at 1013 hPa. It has a measured auto-ignition temperature of 227±3 °C at 1013 hPa and is not oxidising on the basis of chemical structure. The substance is not explosive based on read-across from a structural analogue.
In contact with water, [3-(2,3-epoxypropoxy)propyl]dimethoxy(methyl)silane undergoes rapid hydrolysis (half-life of 1.6 hours at pH 7, 0.1 hours at pH 4 and 0.03 hours at pH 9 and 20-25 °C) to produce [3-(2,3-epoxypropxy)propyl]methylsilanediol and methanol according to the following equation:
CH3Si(OCH3)2(C3H6OC3H5O) + 2H2O → CH3Si(OH)2(C3H6OC3H5O) + 2CH3OH
Therefore, requirements for testing of water-based physicochemical properties for the substance are waived on the basis of instability in water. The properties of the hydrolysis products, [3-(2,3-epoxypropoxy)propyl]methylsilanediol and methanol are assessed instead.
However, the key physicochemical properties of [3-(2,3-epoxypropoxy)propyl]dimethoxy(methyl)silane were predicted with the use of validated QSAR estimation methods. The substance has a predicted log Kow value of 1.7 at 20 °C and water solubility value of 1.2E+04 mg/L at 20 °C.
Methanol is miscible with water, has low log Kow (-0.82 to -0.64) and high vapour pressure (12790 Pa at 20 °C) (OECD 2004).
The saturation concentration in water of the hydrolysis product, [3-(2,3-epoxypropoxy)propyl]methylsilanediol is limited by condensation reactions to approximately 1000 mg/L. However, it is very hydrophilic (calculated solubility is 1.0E+06 mg/L using a QSAR method) and has a low log Kow (-0.7, predicted).
It is not expected to be surface active and it is much less volatile than the parent substance (vapour pressure = 2.8E-04 Pa at 25°C, predicted).
Reference:
OECD (2004). SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18 - 20 October 2004, Methanol, CAS 67-56-1
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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