Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-857-6 | CAS number: 25333-42-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 2002
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Version / remarks:
- 1998
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Germany
- Age at study initiation: at least 6 weeks old
- Weight at study initiation: at least 1.0 kg
- Housing: Individually in labelled cages with perforated floors
- Diet (e.g. ad libitum): Standard Laboratory rabbit diet, approx. 100 g per day. Pressed hay provided twice per week
- Water (e.g. ad libitum): Free access to tap-water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12h dark/12h light
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.4mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 150sq.cm
- Type of wrap if used: Metalline patch 2 x 3 cm. Patch mounted on micropore tape wrapped with Coban elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) hours
SCORING SYSTEM:
- Method of calculation: using numerical scoring system in table 1 below - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Not scored due to eschar formation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- Not scored due to eschar formation
- Irritant / corrosive response data:
- On 25% of the treated surface, black discolouration of the skin (a sign of necrosis) was present after 1 and 24 hours, resulting in eschar formation. A thick black scab was noted after 72 hours. Erythema score 4 was indcated for the aforementioned skin effects. Reactions seen in the remaining skin area (75%) resulted in erythema scores between well defined and moderate to severe erythema. Scoring of oedema was not possible after 48 and 72 hours due to eschar formation and/scab formation.
- Other effects:
- The animal was sacrified for humane reasons after 72 hours based on the severity of the skin effects, and no other animals treated.
No staining of the treated skin by the test substance was observed.
No symptoms of systemic toxicity were observed in the animal during the test period. - Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Remarks:
- Not possible to sub-categorise based on data available
- Conclusions:
- This substance is corrosive to skin under the conditions of the test.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Name:
- 3-(R)-Quinuclidinol
- Implementation:
- EU
- Type of classification:
- self-classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- hazard class not assessed
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Hazard category:
- Flam. Solid 1
- Hazard statement:
- H228: Flammable solid.
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Hazard category:
- Acute Tox. 4
- Hazard statement:
- H302: Harmful if swallowed.
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Hazard category:
- Skin Corr. 1
- Hazard statement:
- H314: Causes severe skin burns and eye damage.
- Hazard category:
- Eye Damage 1
- Hazard statement:
- H318: Causes serious eye damage.
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Signal word:
- Danger
- Code:
- GHS02: flame
- Code:
- GHS05: corrosion
- Code:
- GHS07: exclamation mark
- Hazard statement:
- H228: Flammable solid.
- Hazard statement:
- H302: Harmful if swallowed.
- Hazard statement:
- H314: Causes severe skin burns and eye damage.
- Precautionary statement:
- P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- Precautionary statement:
- P240: Ground and bond container and receiving equipment.
- Precautionary statement:
- P241: Use explosion-proof [electrical/ventilating/lighting/...] equipment.
- Precautionary statement:
- P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
- Precautionary statement:
- P370+P378: In case of fire: Use... to extinguish.
- Precautionary statement:
- P264: Wash ... thoroughly after handling.
- Precautionary statement:
- P270: Do not eat, drink or smoke when using this product.
- Precautionary statement:
- P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
- Precautionary statement:
- P330: Rinse mouth.
- Precautionary statement:
- P302+P352: IF ON SKIN: Wash with plenty of water/…
- Precautionary statement:
- P332+P313: If skin irritation occurs: Get medical advice/attention.
- Precautionary statement:
- P362: Take off contaminated clothing.
- Precautionary statement:
- P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- Precautionary statement:
- P337+P313: If eye irritation persists: Get medical advice/attention.
- Precautionary statement:
- P501: Dispose of contents/container to ...
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.