N-(tri(hydroxymethyl)methyl)glycine

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 Jan 2018 - 18 Mar 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

GLP compliance:

no

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

N-(tri(hydroxymethyl)methyl)glycine

EC Number:

227-193-6

EC Name:

N-(tri(hydroxymethyl)methyl)glycine

Cas Number:

5704-04-1

Molecular formula:

C6H13NO5

IUPAC Name:

2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid

Test material form:

solid: particulate/powder

Results and discussion

Boiling point

Key result

Remarks on result:

not determinable

Any other information on results incl. tables

Preliminary Test: The TGA curve of the test item is shown in Figure 1. Starting at 200°C, the weight of the sample decreased significantly. At 268°C, the sample weight had decreased by 25%. After the experiment, a black charred residue remained in the sample container (original colour: white) and a dark grey residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.

Main Study: The DSC curve obtained with Experiment 1 is shown in Figure 2, see attatchment. An endothermic effect was observed from 175°C on. This endothermic effect was most probably superimposed by an exothermic degradation effect. After the experiment, a brown molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

Conclusion: The boiling temperature of Tricine was tested by DSC. Reaction and/or decomposition of the test item was observed during DSC experiment during or directly after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. 

Applicant's summary and conclusion

Conclusions:

The boiling temperature of Tricine was tested by differential scanning calorimetry (DSC). Reaction and/or decomposition of the test item was observed during DSC experiment during or directly after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

Executive summary:

The boiling temperature of Tricine was tested by differential scanning calorimetry (DSC). Reaction and/or decomposition of the test item was observed during DSC experiment during or directly after melting. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.