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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
p-chloronitrobenzene was found to be a sensitizer
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
- Principles of method if other than guideline:
- 3 drops of a 1 % solution to the clipped area of the skin for 5 d; on d7 1 drop of the 1 % solution to an untreated area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Draize test
- Justification for non-LLNA method:
- modified Draize test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: epicutaneous, 1% solution in aceton
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 1 % 2nd application: Challenge 1 %
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3 drops (10 % sol.) to the clipped area of the skin; 22nd day inj. of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), d28 1 drop (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Freunds complete adjuvant test
- Justification for non-LLNA method:
- modified Freunds complete adjuvant test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- Day(s)/duration:
- Not available
- Adequacy of induction:
- not specified
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 10 % 2nd application: Challenge 10 %
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- N/A
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Group:
- test chemical
- Dose level:
- N/A
- Remarks on result:
- not measured/tested
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
Referenceopen allclose all
No more data given
No more data given
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In an acceptable, well-documented publication which meets basic scientific principles the skin sensitisation potential of 1 -chloro-2 -nitrobenzene was investigated. The study was performed in guinea pigs with 3 drops of a 10% solution to a clipped area of the skin. On the 22nd day Freund-adjuvans was injected with the test substance into the hind paw (0.5 mg/kg bw). 28 days after the first administration 3 drops of the 10 % solution were applied to an untreated clipped area of the skin. The test substance induce sensitisation reactions in 50% of the tested animals.There is sufficient evidence that 1 -chloro-4 -nitrobenzene has a sensitisation potential (Rusakov et al., 1973).
A further indicator to a sensitisation potential of 1 -chloro-4 –nitrobenzene is the comparable chemical structure to the typical sensitizer 2,4-dinitrochlorobenzene. The allergenic activity of p-chloronitrobenzene is less marked than that of 2,4-dinitrochlorobenzene but p-chloronitrobenzene provokes stronger sensitiation effects than o-chloronitrobenzene.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classification:
DSD: Xi, R43. May cause sensitisation by skin contact.
EU-GHS: Skin Sensitisation Category 1. May cause an allergic skin reaction.
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