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Diss Factsheets
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EC number: 701-230-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted Feb. 1987
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of butane-1,4-diol and 1-chloro-2,3-epoxypropane, esters with acrylic acid
- EC Number:
- 701-230-0
- Cas Number:
- 52408-42-1
- Molecular formula:
- C16H26O8
- IUPAC Name:
- Reaction products of butane-1,4-diol and 1-chloro-2,3-epoxypropane, esters with acrylic acid
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Age at study initiation:8-12 weeks
- Weight at study initiation: 2.3 -2.5kg
- Housing: single in suspended cages
- Diet (e.g. ad libitum): Purina rabbit chow (diet #5321) ad lib.
- Water (e.g. ad libitum): ad lib.
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12h / 12h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml - Duration of treatment / exposure:
- substance not washed out
- Observation period (in vivo):
- 28days
Observations after 1h, 24h, 48h, 72h, 7days, 14days, 21days, 28days - Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: Draize + scoring of ocular discharge
0: No discharge
1: Any amount different from normal (does not include small amounts observed in inner canthus of normal animals)
2: Discharge with moistening of the lids and hairs just adjacent to lids
3: Discharge with moistening of the lids and hairs, and considerable area around the eye.
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 28 days
- Remarks on result:
- other: pannus observed on days 7 (2 animals) and 14 (1 animal). Mean individual scores = 2 - 2 - 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days (2 animals), 21 days (1 animal)
- Remarks on result:
- other: Mean individual scores = 2 - 2 - 2.7
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 3 rabbits
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 28 days (1 animal)
- Remarks on result:
- other: Mean individual scores = 3 - 4 - 2
- Irritant / corrosive response data:
- Corneal opacity, noted in 3 of 3 eyes, persisted to day 28 in one eye. Iritis, noted in 3 out of 3 eyes, cleared by day 7. Conjunctival irritation, noted in 3 out of 3 eyes, persisted to day 28 in one eye.
- Other effects:
- There were no abnormal physical signs noted during the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Due to the irreversible effects in 1 animal, the test substance is considered corrosive to the eye.
- Executive summary:
Three rabbits were doses with 0.1 ml of butane-1,4-diylbis(oxy-2-hydroxypropane-3,1-diyl) bisacrylate placed into the left conjunctival sac of each rabbit. The eyes remained unwashed. The eyes were examined and scored by the Draize technique at 1 hour post dose and on days 1, 2, 3, 7, 14, 21 and 28. Body weight were recorded pretest. Corneal opacity, noted in 3 of 3 eyes, persisted to day 28 in one eye. Iritis, noted in 3 out of 3 eyes, cleared by day 7. Conjunctival irritation, noted in 3 out of 3 eyes, persisted to day 28 in one eye. There were no abnormal physical signs noted during the study. Under the conditions of this study, the test article is corrosive based on persistant corneal opacity noted through day 28.
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