Thiamine hydrochloride

Flammability

Link to relevant study record(s)

Reference

Endpoint:

flammable solids

Type of information:

other: Structural assessment

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

GLP compliance:

no

Key result

Test procedure:

other: Burning test ESCIS to determine combustibility index

Remarks on result:

other: The A10 test only has to be performed if the combustability index is ≥ 5. Therefore the test material can be excluded from the classification as flammable solid according to test A10.

Combustibility index of the deposited dust:

BZ = 3 (localised combustion or smoldering, no or only very minor propagation) Temperature = 22 °C (room temperature)

BZ = 4 (spread of a smoldering fire or slow, flameless decomposition) Temperature = 100 °C (elevated temperature)

The A10 test only has to be performed if BZ is ≥ 5. Therefore the test material can be excluded from the classification as flammable solid according to test A10.

Interpretation of results:

other: Not classified in accordance with EU Criteria.

Conclusions:

The test material can be excluded from the classification as a flammable solid according to test A10.

Executive summary:

The burning test ESCIS was used to determine the combustibility index (BZ) of the test material.

The burning behavior at room temperature (20 °C) was BZ=3. The burning behavior at elevated temperature (100 °C) was BZ=4. The A10 test only has to be performed if BZ is ≥ 5.

Therefore thiamine hydrochloride can be excluded from the classification as flammable solid according to test A10.

Description of key information

Flammability (solids)

The test material can be excluded from the classification as a flammable solid according to test A10.

Key value for chemical safety assessment

Flammability:

not classified

Additional information

Flammability (solids)

The burning test ESCIS was used to determine the combustibility index (BZ) of the test material.

The burning behavior at room temperature (20 °C) was BZ=3. The burning behavior at elevated temperature (100 °C) was BZ=4. The A10 test only has to be performed if BZ is ≥ 5.

Therefore thiamine hydrochloride can be excluded from the classification as flammable solid according to test A10.

In accordance with Section 1 of Annex XI of Regulation (EC) No. 1907/2006 (REACH), it is considered justified to omit the Flammability (Contact with Water) and Pyrophoric Properties of Solids and Liquids studies, also required under section 7.10 of Annex VII, on the basis that the testing does not appear to be scientifically necessary.  The chemical structure of the test material contains no groups which would indicate potential reactivity with water or pyrophoric properties.  In addition, experience of handling the material and the known chemical and physical properties of the substance suggest that it is not pyrophoric and is not flammable in contact with water.

Justification for classification or non-classification

In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does not require classification with respect to flammability.