Registration Dossier
Registration Dossier
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EC number: 277-146-9 | CAS number: 72968-71-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Twelve rats (male and female) were exposed to a dust atmosphere of Thermoplastrot Lm 74/400 for 8 hours at a concentration of 2.35 mg/L. After one week the animals were killed and dissected.
- GLP compliance:
- no
- Test type:
- concentration x time method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- EC Number:
- 277-146-9
- EC Name:
- Methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- Cas Number:
- 72968-71-9
- Molecular formula:
- C23H29N7O4S
- IUPAC Name:
- methyl 4-cyano-5-[[5-cyano-2,6-bis[(3-methoxypropyl)amino]-4-methyl-3-pyridyl]azo]-3-methyl-2-thenoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Test material name given in the report: Thermoplastrot Lm 74/400
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- For saturation respective enrichement air was conducted to a layer of 5 cm thickness into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 2.35 mg/liter
- No. of animals per sex per dose:
- 12 animals (m+f)/dose
- Control animals:
- yes
- Details on study design:
- For saturation respective enrichement air was conducted to a layer of 5 cm thickness into the exposure chamber.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- 2.35 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- No deaths occurred.
- Gross pathology:
- No abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No deaths occurred. Discriminating dose = 2.35 mg/L.
- Executive summary:
Twelve rats (male and female) were exposed to a dust atmosphere of Thermoplastrot Lm 74/400 for 8 hours at a concenteration of 2.35 mg/L. After one week the aminals were killed and dissected. No deaths occurred. Discriminating dose = 2.35 mg/L.
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